The chemical biology of naphthoquinones and its environmental implications

Y Kumagai, Y Shinkai, T Miura… - Annual review of …, 2012 - annualreviews.org
Quinones are a group of highly reactive organic chemical species that interact with
biological systems to promote inflammatory, anti-inflammatory, and anticancer actions and to …

1, 4-naphthoquinones: from oxidative damage to cellular and inter-cellular signaling

LO Klotz, X Hou, C Jacob - Molecules, 2014 - mdpi.com
Naphthoquinones may cause oxidative stress in exposed cells and, therefore, affect redox
signaling. Here, contributions of redox cycling and alkylating properties of quinones (both …

Quinone chemistry and toxicity

TJ Monks, RP Hanzlik, GM Cohen, D Ross… - Toxicology and applied …, 1992 - Elsevier
Quinones are ubiquitous in nature and constitute an important class of naturally occurring
compounds that are found in plants, fungi, and bacteria and that function primarily as …

Formation and biological targets of quinones: cytotoxic versus cytoprotective effects

JL Bolton, T Dunlap - Chemical research in toxicology, 2017 - ACS Publications
Quinones represent a class of toxicological intermediates, which can create a variety of
hazardous effects in vivo including, acute cytotoxicity, immunotoxicity, and carcinogenesis …

Naphthoquinones and derivatives as potential anticancer agents: An updated review

MM Rahman, MR Islam, S Akash, S Shohag… - Chemico-Biological …, 2022 - Elsevier
One of the leading global causes of death is cancer; even though several treatment methods
have improved survival rates, the incidence and fatality rates remain high. Naphthoquinones …

Autoxidation of extracellular hydroquinones is a causative event for the cytotoxicity of menadione and DMNQ in A549-S cells

N Watanabe, HJ Forman - Archives of Biochemistry and Biophysics, 2003 - Elsevier
Cytotoxicity of 1, 4-naphthoquinones has been attributed to intracellular reactive oxygen
species (ROS) generation through one-electron-reductase-mediated redox cycling and to …

Role of quinones in toxicology

JL Bolton, MA Trush, TM Penning… - Chemical research in …, 2000 - ACS Publications
Quinones represent a class of toxicological intermediates which can create a variety of
hazardous effects in vivo, including acute cytotoxicity, immunotoxicity, and carcinogenesis …

The metabolism and toxicity of quinones, quinonimines, quinone methides, and quinone-thioethers

TJ Monks, DC Jones - Current drug metabolism, 2002 - ingentaconnect.com
Quinones are ubiquitous in nature and constitute an important class of naturally occurring
compounds found in plants, fungi and bacteria. Human exposure to quinones therefore …

Mechanisms of toxicity of naphthoquinones to isolated hepatocytes

MG Miller, A Rodgers, GM CoHEN - Biochemical pharmacology, 1986 - Elsevier
The possible mechanisms of naphthoquinone-induced toxicity to isolated hepatocytes were
investigated using three structurally-related naphthoquinones, 1, 4-naphthoquinone (1, 4 …

Understanding cancer and the anticancer activities of naphthoquinones–a review

KW Wellington - RSC advances, 2015 - pubs.rsc.org
The non-communicable disease, cancer, is one of the major causes of death across the
world and is forecast to increase by 75% to reach close to 25 million cases over the next two …