Redox active secondary metabolites
Various secondary metabolites from plants, bacteria and fungi are redox active and able to
modulate the intracellular redox equilibrium in living cells. Many of these compounds …
modulate the intracellular redox equilibrium in living cells. Many of these compounds …
Biological targets of isothiocyanates
KK Brown, MB Hampton - Biochimica et Biophysica Acta (BBA)-General …, 2011 - Elsevier
BACKGROUND: Isothiocyanates are phytochemicals with a broad array of effects in
biological systems. Bioactivity includes the stimulation of cellular antioxidant systems …
biological systems. Bioactivity includes the stimulation of cellular antioxidant systems …
Redox ticklers and beyond: Naphthoquinone repository in the spotlight against inflammation and associated maladies
Cellular redox status has been considered as a focal point for the pathogenesis of multiple
disorders. High and persistent levels of free radicals kick off inflammation and associated …
disorders. High and persistent levels of free radicals kick off inflammation and associated …
Mitochondrial peroxiredoxin 3 is rapidly oxidized in cells treated with isothiocyanates
KK Brown, SE Eriksson, ESJ Arnér… - Free Radical Biology and …, 2008 - Elsevier
Isothiocyanates are phytochemicals with anti-cancer properties that include the ability to
trigger apoptosis. A substantial body of evidence suggests that reaction of the electrophilic …
trigger apoptosis. A substantial body of evidence suggests that reaction of the electrophilic …
Cancer-preventive isothiocyanates: dichotomous modulators of oxidative stress
Isothiocyanates (ITCs), a class of phytochemicals with promising cancer-preventive
potential, are double-edged swords in the modulation of cellular oxidative stress. While ITCs …
potential, are double-edged swords in the modulation of cellular oxidative stress. While ITCs …
Synthesis and structure–activity relations in allylsulfide and isothiocyanate compounds from garlic and broccoli against in vitro cancer cell growth
CH Kaschula, R Hunter - Studies in Natural Products Chemistry, 2016 - Elsevier
The edible plants garlic (Allium sativum) and broccoli (Brassica olevacea) are rich in sulfur-
containing compounds that are reported to offer protection against a number of diseases …
containing compounds that are reported to offer protection against a number of diseases …
Redox-active and redox-silent compounds: synergistic therapeutics in cancer
M Tomasetti, L Santarelli, R Alleva… - Current Medicinal …, 2015 - ingentaconnect.com
Tumours exhibit higher basal levels of reactive oxygen species (ROS) and altered redox
environment compared to normal cells. Excessive level of ROS can be toxic to these cells …
environment compared to normal cells. Excessive level of ROS can be toxic to these cells …
The anti-oxidant properties of isothiocyanates: a review
S M. de Figueiredo, S AV Filho… - Recent patents on …, 2013 - benthamdirect.com
Cruciferous vegetables, such as broccoli and watercress, have been studied extensively
aiming to evaluate their chemopreventive properties. Some of them have already been …
aiming to evaluate their chemopreventive properties. Some of them have already been …
Redox platforms in cancer drug discovery and development
KD Tew, DM Townsend - Current opinion in chemical biology, 2011 - Elsevier
Redox homeostasis is frequently dysregulated in human disease, particularly cancer.
Recent and ongoing efforts seek to validate and extend this platform for the discovery …
Recent and ongoing efforts seek to validate and extend this platform for the discovery …
Isothiocyanates: a class of bioactive metabolites with chemopreventive potential
In recent years, growing interest has been focused on the field of chemoprevention using
natural therapies. The reason to turn toward “natural” remedies is associated with diverse …
natural therapies. The reason to turn toward “natural” remedies is associated with diverse …