Redox active secondary metabolites

C Jacob, V Jamier, LA Ba - Current Opinion in Chemical Biology, 2011 - Elsevier
Various secondary metabolites from plants, bacteria and fungi are redox active and able to
modulate the intracellular redox equilibrium in living cells. Many of these compounds …

Biological targets of isothiocyanates

KK Brown, MB Hampton - Biochimica et Biophysica Acta (BBA)-General …, 2011 - Elsevier
BACKGROUND: Isothiocyanates are phytochemicals with a broad array of effects in
biological systems. Bioactivity includes the stimulation of cellular antioxidant systems …

Redox ticklers and beyond: Naphthoquinone repository in the spotlight against inflammation and associated maladies

N Kapoor, P Kandwal, G Sharma, L Gambhir - Pharmacological Research, 2021 - Elsevier
Cellular redox status has been considered as a focal point for the pathogenesis of multiple
disorders. High and persistent levels of free radicals kick off inflammation and associated …

Mitochondrial peroxiredoxin 3 is rapidly oxidized in cells treated with isothiocyanates

KK Brown, SE Eriksson, ESJ Arnér… - Free Radical Biology and …, 2008 - Elsevier
Isothiocyanates are phytochemicals with anti-cancer properties that include the ability to
trigger apoptosis. A substantial body of evidence suggests that reaction of the electrophilic …

Cancer-preventive isothiocyanates: dichotomous modulators of oxidative stress

Y Zhang, J Li, L Tang - Free Radical Biology and Medicine, 2005 - Elsevier
Isothiocyanates (ITCs), a class of phytochemicals with promising cancer-preventive
potential, are double-edged swords in the modulation of cellular oxidative stress. While ITCs …

Synthesis and structure–activity relations in allylsulfide and isothiocyanate compounds from garlic and broccoli against in vitro cancer cell growth

CH Kaschula, R Hunter - Studies in Natural Products Chemistry, 2016 - Elsevier
The edible plants garlic (Allium sativum) and broccoli (Brassica olevacea) are rich in sulfur-
containing compounds that are reported to offer protection against a number of diseases …

Redox-active and redox-silent compounds: synergistic therapeutics in cancer

M Tomasetti, L Santarelli, R Alleva… - Current Medicinal …, 2015 - ingentaconnect.com
Tumours exhibit higher basal levels of reactive oxygen species (ROS) and altered redox
environment compared to normal cells. Excessive level of ROS can be toxic to these cells …

The anti-oxidant properties of isothiocyanates: a review

S M. de Figueiredo, S AV Filho… - Recent patents on …, 2013 - benthamdirect.com
Cruciferous vegetables, such as broccoli and watercress, have been studied extensively
aiming to evaluate their chemopreventive properties. Some of them have already been …

Redox platforms in cancer drug discovery and development

KD Tew, DM Townsend - Current opinion in chemical biology, 2011 - Elsevier
Redox homeostasis is frequently dysregulated in human disease, particularly cancer.
Recent and ongoing efforts seek to validate and extend this platform for the discovery …

Isothiocyanates: a class of bioactive metabolites with chemopreventive potential

G Kumar, HS Tuli, S Mittal, JK Shandilya, A Tiwari… - Tumor Biology, 2015 - Springer
In recent years, growing interest has been focused on the field of chemoprevention using
natural therapies. The reason to turn toward “natural” remedies is associated with diverse …