Sixteen novel naphthoquinone aromatic amides were synthesized by a new route starting
from 1-hydroxy-2-naphthoic acid in nine or ten steps with good to excellent yield. Amide …

Fourteen new naphthoquinone aliphatic amides and seventeen naphthoquinone aliphatic
esters were synthesized in nine to ten steps from 1-hydroxy-2-naphthoic acid with 9–25 …

Abstract Quinones such as 1, 4-naphthoquinones are abundant in nature and
naphthoquinone based natural products are known to possess anticancer activity. This …

To examine the effect of hydrophobicity on the anticancer activity of 1, 4-naphthoquinone
derivatives, a series of compounds bearing a 2-O-alkyl-, 3-C-alkyl-or 2/3-N-morpholinoalkyl …

Naphthoquinones are exceptional building blocks in organic synthesis and have been used
to synthesize several well‐known pharmaceutically active agents. Herein we report the …

Introduction: A large number of natural products including several synthetic drugs possess
naphthoquinone chromophore. Various methods have been devised for their synthesis …

Rhinacanthone (1) and two 1, 2-pyranonaphthoquinones (2, 3) were synthesized and found
to show very potent cytotoxicity against three cancer cell lines (KB, HeLa and HepG2) with …

Cancer encompasses a group of pathologies with common characteristics, high incidence,
and prevalence in all countries. Although there are treatments available for this disease …

We performed an extensive analysis about the reaction conditions of the 1, 4-Michael
addition of amino acids to 1, 4-naphthoquinone and substitution to 2, 3 …

The cytotoxicity of a series of aminonaphthoquinones resulting from the reaction of suitable
aminoacids with 1, 4-naphthoquinone was assayed against SF-295 (glioblastoma), MDAMB …