Isothiocyanates: a class of bioactive metabolites with chemopreventive potential

G Kumar, HS Tuli, S Mittal, JK Shandilya, A Tiwari… - Tumor Biology, 2015 - Springer
In recent years, growing interest has been focused on the field of chemoprevention using
natural therapies. The reason to turn toward “natural” remedies is associated with diverse …

[PDF][PDF] Role of isothiocyanates as anticancer agents and their contributing molecular and cellular mechanisms

G Rampal, N Khanna, TS Thind, S Arora… - Med. Chem. Drug …, 2012 - researchgate.net
Consumption of cruciferous vegetables is strongly associated with cancer protection.
Crucifers contain many bioactive components; among the most-studied bioactive …

Mechanisms of the anticancer effects of isothiocyanates

NM Fofaria, A Ranjan, SH Kim, SK Srivastava - The enzymes, 2015 - Elsevier
Cancer results from aberrant signaling pathways that result in uncontrolled cellular
proliferation. The epidemiological studies have shown a strong inverse correlation between …

Molecular targets of isothiocyanates in cancer: recent advances

P Gupta, B Kim, SH Kim… - Molecular nutrition & food …, 2014 - Wiley Online Library
Cancer is a multistep process resulting in uncontrolled cell division. It results from aberrant
signaling pathways that lead to uninhibited cell division and growth. Various recent …

Exploring the effects of isothiocyanates on chemotherapeutic drugs

A Minarini, A Milelli, C Fimognari, E Simoni… - Expert Opinion on …, 2014 - Taylor & Francis
Introduction: Chemoprevention has emerged as a promising strategy to reduce the risk and
to control cancer. In this context, isothiocyanates (ITCs), found in abundance in the form of …

Mechanisms of action of isothiocyanates in cancer chemoprevention: an update

SL Navarro, F Li, JW Lampe - Food & function, 2011 - pubs.rsc.org
Isothiocyanates (ITC), derived from glucosinolates, are thought to be responsible for the
chemoprotective actions conferred by higher cruciferous vegetable intake. Evidence …

Dietary isothiocyanates: Novel insights into the potential for cancer prevention and therapy

G Na, C He, S Zhang, S Tian, Y Bao… - International Journal of …, 2023 - mdpi.com
Diet plays an important role in health. A high intake of plant chemicals such as
glucosinolates/isothiocyanates can promote optimal health and decrease the risk of cancer …

The role of isothiocyanates as cancer chemo-preventive, chemo-therapeutic and anti-melanoma agents

M Mitsiogianni, G Koutsidis, N Mavroudis, DT Trafalis… - Antioxidants, 2019 - mdpi.com
Many studies have shown evidence in support of the beneficial effects of phytochemicals in
preventing chronic diseases, including cancer. Among such phytochemicals, sulphur …

The molecular basis that unifies the metabolism, cellular uptake and chemopreventive activities of dietary isothiocyanates

Y Zhang - Carcinogenesis, 2012 - academic.oup.com
Organic isothiocyanates (ITCs), which are characterized by the presence of an–N= C= S
group, are among the most extensively studied cancer chemopreventive agents and show …

Chemoprevention with isothiocyanates–From bench to bedside

C Gründemann, R Huber - Cancer letters, 2018 - Elsevier
Isothiocyanates (ITCs) are naturally occurring hydrolization products from glucosinolates
(GLSs) in brassicaceae and in epidemiological studies their intake has been weakly to …