A series of 5-hydroxy-1, 4-naphthoquinones analogues was synthesized from juglone (6)
and their antiproliferative activity against a representative panel of six human solid tumor cell …

A series of 17 selected natural and semisynthetic 1, 4-naphthoquinones were synthesized,
and their growth inhibitory activity was evaluated in vitro. The compounds were tested on six …

Naphthoquinones have been found to have a wide range of biological activities, including
cytotoxicity to cancer cells. The secondary metabolites lapachol, α-and β-lapachone and a …

A synthetic method to obtain α-and β-pyran naphthoquinones 10 and 11 with a hydroxyl
substituent on the aromatic ring was developed. Two series of α-and β-pyran …

Ozonolysis of lapachol (1), resulting in an unusual formation of a potent antitumor agent 2-
acetylfuranonaphthoquinone (3) along with the expected aldehyde 6, is described. The …

The non-communicable disease, cancer, is one of the major causes of death across the
world and is forecast to increase by 75% to reach close to 25 million cases over the next two …

Naphthoquinones are considered privileged structures for anticancer drug molecules. The
Heck reaction of 2‐hydroxy‐1, 4‐naphthoquinone (lawsone) with 1‐bromo‐3‐methyl‐2 …

Since the finding that lapachol (1), a natural 1, 4-naphthoquinone isolated from the Lapacho
trees, displays antitumor activity against carcinoma Walker 256, many other natural and …

Several 3-arylamino and 3-alkoxy-nor-β-lapachone derivatives were synthesized in
moderate to high yields and found to be highly potent against cancer cells SF295 (central …

Novel naphthoquinone-based chalcones were prepared from the reaction between 3-bromo-
nor-β-lapachone and amino-chalcones. Lapachone derivatives are also described here. All …