Several members of the phenylamino-1, 4-naphthoquinone series were prepared in order to
investigate structure–activity relationships (SAR) and to explore the antitumor effects …

The cytotoxicity of a series of aminonaphthoquinones resulting from the reaction of suitable
aminoacids with 1, 4-naphthoquinone was assayed against SF-295 (glioblastoma), MDAMB …

A series of 2-substituted amino-3-chloro-1, 4-naphthoquinone derivatives (3–12) were
synthesized as anticancer agents and tested against four cancer cell lines including HepG2 …

All of 13 (E)-6-(1-alkyloxyiminomethyl)-5, 8-dimethoxy-1, 4-naphthoquinone derivatives
synthesized showed high ED50 values, ranging from 0.1 to 0.3 μg/mL against L1210 cells …

To examine the effect of hydrophobicity on the anticancer activity of 1, 4-naphthoquinone
derivatives, a series of compounds bearing a 2-O-alkyl-, 3-C-alkyl-or 2/3-N-morpholinoalkyl …

Naphthoquinones are widely distributed in nature and many clinically important antitumor
drugs containing a quinone moiety, such as anthracyclines, mitoxantrones and saintopin …

Abstract A novel series of 1, 4-naphthoquinones (33–44) tethered by open and closed chain
sulfonamide moieties were designed, synthesized and evaluated for their cytotoxic and …

To establish the structure-activity relationship of 5-hydroxy-1, 4-naphthoquinones toward
anticancer activity, a series of its derivatives were prepared and tested for the activity (IC 50 …

Eleven 2, 3-(substituted)-1, 4-naphthoquinone derivatives were synthesized in yields
ranging from 52-89%. These derivatives were evaluated for their cytotoxic effects on human …

Abstract Morita-Baylis-Hillman acetates and α-bromonitroalkenes have been employed in
cascade reactions with lawsone and 2-aminonaphthoquinone for the one-pot synthesis of …