Naphthoquinones are widely distributed in nature and many clinically important antitumor
drugs containing a quinone moiety, such as anthracyclines, mitoxantrones and saintopin …

Naphthoquinones (1, 4-NQ) have been reported to possess a variety of pharma-cological
properties including antibacterial, antifungal, antiviral, anti-inflammatory, anti …

To establish the structure-activity relationship of 5-hydroxy-1, 4-naphthoquinones toward
anticancer activity, a series of its derivatives were prepared and tested for the activity (IC 50 …

Rhinacanthone (1) and two 1, 2-pyranonaphthoquinones (2, 3) were synthesized and found
to show very potent cytotoxicity against three cancer cell lines (KB, HeLa and HepG2) with …

All of 13 (E)-6-(1-alkyloxyiminomethyl)-5, 8-dimethoxy-1, 4-naphthoquinone derivatives
synthesized showed high ED50 values, ranging from 0.1 to 0.3 μg/mL against L1210 cells …

In the present study substituted 1, 2-naphthoquinones were synthesized, purified and
characterized by spectroscopic studies (UV, FT-IR, 1 H NMR, 13 C NMR and elemental …

Naphthoquinones are exceptional building blocks in organic synthesis and have been used
to synthesize several well‐known pharmaceutically active agents. Herein we report the …

To examine the effect of hydrophobicity on the anticancer activity of 1, 4-naphthoquinone
derivatives, a series of compounds bearing a 2-O-alkyl-, 3-C-alkyl-or 2/3-N-morpholinoalkyl …

In an effort to develop potent and selective antitumor agents, a series of 1, 4-
naphthoquinone oxime derivatives were designed and synthesized. The cytotoxicity of these …

The cytotoxicity of a series of aminonaphthoquinones resulting from the reaction of suitable
aminoacids with 1, 4-naphthoquinone was assayed against SF-295 (glioblastoma), MDAMB …