Cancer-preventive isothiocyanates: dichotomous modulators of oxidative stress

Y Zhang, J Li, L Tang - Free Radical Biology and Medicine, 2005 - Elsevier
Isothiocyanates (ITCs), a class of phytochemicals with promising cancer-preventive
potential, are double-edged swords in the modulation of cellular oxidative stress. While ITCs …

Biological targets of isothiocyanates

KK Brown, MB Hampton - Biochimica et Biophysica Acta (BBA)-General …, 2011 - Elsevier
BACKGROUND: Isothiocyanates are phytochemicals with a broad array of effects in
biological systems. Bioactivity includes the stimulation of cellular antioxidant systems …

The molecular basis that unifies the metabolism, cellular uptake and chemopreventive activities of dietary isothiocyanates

Y Zhang - Carcinogenesis, 2012 - academic.oup.com
Organic isothiocyanates (ITCs), which are characterized by the presence of an–N= C= S
group, are among the most extensively studied cancer chemopreventive agents and show …

Mechanisms of action of isothiocyanates in cancer chemoprevention: an update

SL Navarro, F Li, JW Lampe - Food & function, 2011 - pubs.rsc.org
Isothiocyanates (ITC), derived from glucosinolates, are thought to be responsible for the
chemoprotective actions conferred by higher cruciferous vegetable intake. Evidence …

Vegetable-derived isothiocyanates: anti-proliferative activity and mechanism of action

Y Zhang, S Yao, J Li - Proceedings of the Nutrition Society, 2006 - cambridge.org
Many isothiocyanates (ITC), which are available to human subjects mainly through
consumption of cruciferous vegetables, demonstrate strong cancer-preventive activity in …

The role of isothiocyanates as cancer chemo-preventive, chemo-therapeutic and anti-melanoma agents

M Mitsiogianni, G Koutsidis, N Mavroudis, DT Trafalis… - Antioxidants, 2019 - mdpi.com
Many studies have shown evidence in support of the beneficial effects of phytochemicals in
preventing chronic diseases, including cancer. Among such phytochemicals, sulphur …

Cancer-preventive isothiocyanates: measurement of human exposure and mechanism of action

Y Zhang - … Research/Fundamental and Molecular Mechanisms of …, 2004 - Elsevier
Numerous studies in rodents have documented the cancer-preventive activity of a significant
number of isothiocyanates (ITCs), the majority of which occur in plants, especially in …

Chemoprevention by isothiocyanates: molecular basis of apoptosis induction

Y Nakamura - Food Factors for Health Promotion, 2009 - karger.com
An important and promising group of compounds that have a cancer-chemopreventive
property are organosulfur compounds, such as isothiocyanates (ITCs). Various ITCs are …

Chemoprotection against cancer by isothiocyanates: a focus on the animal models and the protective mechanisms

AT Dinkova-Kostova - Natural Products in Cancer Prevention and Therapy, 2013 - Springer
The isothiocyanates are among the most extensively studied chemoprotective agents. They
are derived from glucosinolate precursors by the action of β-thioglucosidase enzymes …

Cancer chemoprevention with dietary isothiocyanates mature for clinical translational research

SV Singh, K Singh - Carcinogenesis, 2012 - academic.oup.com
Inverse association between dietary intake of cruciferous vegetables and cancer risk
observed in population-based case-control studies is partly attributable to structurally simple …