Synthesis and structure–activity relations in allylsulfide and isothiocyanate compounds from garlic and broccoli against in vitro cancer cell growth

CH Kaschula, R Hunter - Studies in Natural Products Chemistry, 2016 - Elsevier
The edible plants garlic (Allium sativum) and broccoli (Brassica olevacea) are rich in sulfur-
containing compounds that are reported to offer protection against a number of diseases …

Allyl sulfur compounds and cellular detoxification system: effects and perspectives in cancer therapy

S Melino, R Sabelli, M Paci - Amino acids, 2011 - Springer
Natural organosulfur compounds (OSCs) have been shown to have chemopreventive effects
and to suppress the proliferation of tumor cells in vitro through the induction of apoptosis …

Natural polysulfides-Reactive sulfur species from Allium with applications in medicine and agriculture

A Anwar - 2009 - publikationen.sulb.uni-saarland.de
Natural sulfur compounds from plants, bacteria, fungi and animals frequently exhibit
interesting biological activities, such as antioxidant, antimicrobial and anticancer activity …

[HTML][HTML] Redox-sensitive proteins are potential targets of garlic-derived mercaptocysteine derivatives

JT Pinto, BF Krasnikov, AJL Cooper - The Journal of nutrition, 2006 - Elsevier
Molecular investigations support existing clinical and epidemiological data that garlic-
derived allylsulfides reduce cancer risk. Various allylsulfides can diminish progression of …

Differentiating Antiproliferative and Chemopreventive Modes of Activity for Electron‐Deficient Aryl Isothiocyanates against Human MCF‐7 Cells

RH Anderson, CJ Lensing, BJ Forred… - …, 2018 - Wiley Online Library
The consumption of Brassica vegetables provides beneficial effects through organic
isothiocyanates (ITCs), products of the enzymatic hydrolysis of glucosinolate secondary …

An appraisal of developments in allium sulfur chemistry: expanding the pharmacopeia of garlic

P Rose, PK Moore, M Whiteman, YZ Zhu - Molecules, 2019 - mdpi.com
Alliums and allied plant species are rich sources of sulfur compounds that have effects on
vascular homeostasis and the control of metabolic systems linked to nutrient metabolism in …

Polysulfides as biologically active ingredients of garlic

U Münchberg, A Anwar, S Mecklenburg… - Organic & biomolecular …, 2007 - pubs.rsc.org
Garlic has long been considered as a natural remedy against a range of human illnesses,
including various bacterial, viral and fungal infections. This kind of antibiotic activity of garlic …

Isothiocyanate synthetic analogs: Biological activities, structure-activity relationships and synthetic strategies

A Milelli, C Fimognari, N Ticchi… - Mini Reviews in …, 2014 - ingentaconnect.com
Sulforaphane is a natural product that is constantly under biological investigation for its
unique biological properties. This naturally occurring isothiocyanate (ITC) and its analogs …

[PDF][PDF] Allicin from garlic, effective in controlling several plant diseases, is a reactive sulfur species (RSS) that pushes cells into apoptosis.

MC Gruhlke, I Nwachwukwu, M Arbach, A Anwar… - 2011 - d-nb.info
The volatile antimicrobial substance allicin (diallylthiosulfinate) is produced in garlic when
the tissues are damaged and the substrate alliin (S-allyl-L-cysteine sulfoxide) mixes with the …

Anticancerous sulfides from onion, Welsh onion, and garlic

T Nohara, Y Fujiwara, M El-Aasr, T Ikeda, M Ono… - Studies in Natural …, 2024 - Elsevier
This chapter reviews our work over the last 10 years, in which we looked at the sulfides in
the acetone extracts of garlic (Allium sativum), onion (Allium cepa), and Welsh onion (Allium …