Proteins as binding targets of isothiocyanates in cancer prevention

L Mi, AJ Di Pasqua, FL Chung - Carcinogenesis, 2011 - academic.oup.com
Isothiocyanates are versatile cancer-preventive compounds. Evidence from animal studies
indicates that the anticarcinogenic activities of ITCs involve all the major stages of tumor …

Identification of potential protein targets of isothiocyanates by proteomics

L Mi, BL Hood, NA Stewart, Z Xiao… - Chemical research in …, 2011 - ACS Publications
Isothiocyanates (ITCs), such as phenethyl isothiocyanate (PEITC) and sulforaphane (SFN),
are effective cancer chemopreventive compounds. It is believed that the major mechanism …

Mechanisms of the anticancer effects of isothiocyanates

NM Fofaria, A Ranjan, SH Kim, SK Srivastava - The enzymes, 2015 - Elsevier
Cancer results from aberrant signaling pathways that result in uncontrolled cellular
proliferation. The epidemiological studies have shown a strong inverse correlation between …

Cancer-preventive isothiocyanates: measurement of human exposure and mechanism of action

Y Zhang - … Research/Fundamental and Molecular Mechanisms of …, 2004 - Elsevier
Numerous studies in rodents have documented the cancer-preventive activity of a significant
number of isothiocyanates (ITCs), the majority of which occur in plants, especially in …

The molecular basis that unifies the metabolism, cellular uptake and chemopreventive activities of dietary isothiocyanates

Y Zhang - Carcinogenesis, 2012 - academic.oup.com
Organic isothiocyanates (ITCs), which are characterized by the presence of an–N= C= S
group, are among the most extensively studied cancer chemopreventive agents and show …

Isothiocyanates as novel cytotoxic and cytostatic agents: molecular pathway on human transformed and non-transformed cells

C Fimognari, M Nüsse, F Berti, R Iori… - Biochemical …, 2004 - Elsevier
Cancer chemoprevention is a new approach in the management of cancer. Traditional
cytotoxic chemotherapeutic approaches cannot cure most advanced solid malignancies …

Selected isothiocyanates rapidly induce growth inhibition of cancer cells

Y Zhang, L Tang, V Gonzalez - Molecular cancer therapeutics, 2003 - AACR
Many plant-derived isothiocyanates (ITCs), which occur in human diet, are potent cancer
chemopreventive agents in animals. Among the anticarcinogenic mechanisms that have …

Vegetable-derived isothiocyanates: anti-proliferative activity and mechanism of action

Y Zhang, S Yao, J Li - Proceedings of the Nutrition Society, 2006 - cambridge.org
Many isothiocyanates (ITC), which are available to human subjects mainly through
consumption of cruciferous vegetables, demonstrate strong cancer-preventive activity in …

Molecular targets of isothiocyanates in cancer: recent advances

P Gupta, B Kim, SH Kim… - Molecular nutrition & food …, 2014 - Wiley Online Library
Cancer is a multistep process resulting in uncontrolled cell division. It results from aberrant
signaling pathways that lead to uninhibited cell division and growth. Various recent …

The role of isothiocyanates as cancer chemo-preventive, chemo-therapeutic and anti-melanoma agents

M Mitsiogianni, G Koutsidis, N Mavroudis, DT Trafalis… - Antioxidants, 2019 - mdpi.com
Many studies have shown evidence in support of the beneficial effects of phytochemicals in
preventing chronic diseases, including cancer. Among such phytochemicals, sulphur …