Recent development on naphthoquinone derivatives and their therapeutic applications as anticancer agents

VK Tandon, S Kumar - Expert Opinion on Therapeutic Patents, 2013 - Taylor & Francis
Introduction: A large number of natural products including several synthetic drugs possess
naphthoquinone chromophore. Various methods have been devised for their synthesis …

Naphthoquinones: A continuing source for discovery of therapeutic antineoplastic agents

HY Qiu, PF Wang, HY Lin, CY Tang… - Chemical biology & …, 2018 - Wiley Online Library
Naturally occurring naphthoquinones, usually in forms of botanical extracts, have been
implicated with human life since ancient time, far earlier than their isolation and identification …

[HTML][HTML] Unlocking the potential of 1, 4-naphthoquinones: A comprehensive review of their anticancer properties

E Angulo-Elizari, A Henriquez-Figuereo… - European Journal of …, 2024 - Elsevier
Cancer encompasses a group of pathologies with common characteristics, high incidence,
and prevalence in all countries. Although there are treatments available for this disease …

Understanding cancer and the anticancer activities of naphthoquinones–a review

KW Wellington - RSC advances, 2015 - pubs.rsc.org
The non-communicable disease, cancer, is one of the major causes of death across the
world and is forecast to increase by 75% to reach close to 25 million cases over the next two …

The diverse mechanisms and anticancer potential of naphthoquinones

CE Pereyra, RF Dantas, SB Ferreira, LP Gomes… - Cancer Cell …, 2019 - Springer
Cancer is one of the leading causes of death around the world and although the different
clinical approaches have helped to increase survival rates, incidence is still high and so its …

Naphthoquinones and derivatives as potential anticancer agents: An updated review

MM Rahman, MR Islam, S Akash, S Shohag… - Chemico-Biological …, 2022 - Elsevier
One of the leading global causes of death is cancer; even though several treatment methods
have improved survival rates, the incidence and fatality rates remain high. Naphthoquinones …

Synthesis and cytotoxic evaluation of a series of 2-amino-naphthoquinones against human cancer cells

TAP De Moraes, MJS Filha, CA Camara, TMS Silva… - Molecules, 2014 - mdpi.com
The cytotoxicity of a series of aminonaphthoquinones resulting from the reaction of suitable
aminoacids with 1, 4-naphthoquinone was assayed against SF-295 (glioblastoma), MDAMB …

Synthesis, characterization and antiproliferative activity of 1, 2-naphthoquinone and its derivatives

S Shukla, RS Srivastava, SK Shrivastava… - Applied biochemistry …, 2012 - Springer
In the present study substituted 1, 2-naphthoquinones were synthesized, purified and
characterized by spectroscopic studies (UV, FT-IR, 1 H NMR, 13 C NMR and elemental …

First synthesis and anticancer activity of novel naphthoquinone amides

N Pradidphol, N Kongkathip, P Sittikul… - European journal of …, 2012 - Elsevier
Sixteen novel naphthoquinone aromatic amides were synthesized by a new route starting
from 1-hydroxy-2-naphthoic acid in nine or ten steps with good to excellent yield. Amide …

Synthesis and anticancer evaluation of 1, 4‐naphthoquinone derivatives containing a phenylaminosulfanyl moiety

P Ravichandiran, SA Subramaniyan, SY Kim… - …, 2019 - Wiley Online Library
Naphthoquinones are exceptional building blocks in organic synthesis and have been used
to synthesize several well‐known pharmaceutically active agents. Herein we report the …