A characteristic feature of vertebrate cells is a Golgi ribbon consisting of multiple cisternal
stacks connected into a single-copy organelle next to the centrosome. Despite numerous …

An organelle is a membrane-bounded intracellular structure with a unique molecular
composition and function. Where do organelles come from? Most biologists would state that …

To describe trafficking of secretory cargo within the Golgi apparatus, the cisternal maturation
model predicts that Golgi cisternae change their properties from cis to trans while cargo …

Regulated secretion is a fundamental cellular process in which biologically active molecules
stored in long-lasting secretory granules (SGs) are secreted in response to external stimuli …

The secretory pathway of eucaryotic cells consists of distinct membrane-bound organelles
and transport vesicles that collectively function to transport proteins to the cell surface (1) …

The recent identification of an endoplasmic reticulum-Golgi intermediate compartment has
added to the complexity of the structural and functional organization of the early secretory …

Publisher Summary The organized and characteristic elements of the Golgi complex (GC)
are the stacked smooth-surfaced cisternae, which are found in the centrosphere of all …

After leaving the endoplasmic reticulum, secretory proteins traverse several membranous
transport compartments before reaching their destinations. How they move through the Golgi …

The early endosome (EE), also known as the sorting endosome (SE) is a crucial station for
the sorting of cargoes, such as receptors and lipids, through the endocytic pathways. The …

Recent studies using GFP-tagged markers and time-lapse microscopy have allowed direct
visualisation of membrane traffic in the secretory pathway in living mammalian cells. This …