… in the production of stable and effective antibody fragments. This review will discuss both …
antibody fragments and an overview of possible future avenues for generating fragments with …

… different types of antibody fragments with improved structure … the various types of antibody
fragments and their applications for … Mechanisms of antitumor action of antibody fragments as …

… In conclusion, antibodies and antibody fragments have added significantly to the portfolio
of available therapeutics and are likely to continue to do so with the many advances being …

… One possible approach to circumvent the BBB challenge is to express antibody fragments,
termed intrabodies, within the cells of the brain. Although this approach may be far from …

… antibodies, a large body of work has focused on the generation of small non-antibody …
In this review, we discuss challenges in translating such scaffolds into validated drugs, and …

… antibodies and 18 next generation fragment or recombinant fusion antibody-based therapies
are approved for clinical use, with hundreds more in clinical trials expected to reach market. …

… As this review aims to show, there is tremendous potential for all antibody fragments either
as robust … The challenges in engineering antibody binding sites are underlined by a series of …

… control tissues and negative control antibody (irrelevant IgG) should be included in all
studies. If a conjugated, chemically-modified antibody or an antibody fragment is to be used …

… ) via bispecific antibody fragments and/or scFv (single chain variable fragments or Ab-ligand …
2 fusion proteins; antibody drug conjugates (ADCs); and antibody-directed enzyme prodrug …

… This review would provide a comprehensive guidance for the researchers who are interested
in and intended to involve in the antibodies- or antibody fragments-based tumor immunity. …