Combined administration of systemic and topical tranexamic acid for total knee arthroplasty: can it be a better regimen and yet safe? A randomized controlled trial

NP Jain, PP Nisthane, NA Shah - The Journal of arthroplasty, 2016 - Elsevier
… as well as combined intravenous and intraarticular TXA administration in the present study.
… that combined administration of IV and IA TXA is more effective than IV TXA administration

… combined effect of administration of intravenous and topical tranexamic acid on blood loss and transfusion rate in total knee arthroplasty: combined tranexamic acid …

ZF Yuan, H Yin, WP Ma, DL Xing - Bone & joint research, 2016 - boneandjoint.org.uk
administration, the combined IV and IA application of TXA, has been applied in TKA. However,
the scientific evidence of combined administration … and safety of combined IV and IA TXA …

A systematic review and meta-analysis comparing combined intravenous and topical tranexamic acid with intravenous administration alone in THA

Y Sun, C Jiang, Q Li - PLoS One, 2017 - journals.plos.org
combined administration was still unclear[17]. In our meta-analysis, all studies reported the
dose for combined TXA administration… g or less for combined administration. Rajesparan et al[…

… acid administration in primary total hip arthroplasty: a randomized controlled trial of intravenous combined with topical versus single-dose intravenous administration

Z Yi, S Bin, Y Jing, Z Zongke, K Pengde, P Fuxing - JBJS, 2016 - journals.lww.com
… The use of tranexamic acid (TXA) in primary total hip arthroplasty is well documented. …
safety of intravenous (IV) administration combined with topical administration of TXA regarding …

The efficacy and safety of combined administration of intravenous and topical tranexamic acid in primary total knee arthroplasty: a meta-analysis of randomized …

H Xiong, Y Liu, Y Zeng, Y Wu, B Shen - BMC musculoskeletal disorders, 2018 - Springer
… of intravenous (IV) and topical tranexamic acid (TXA) in … the efficacy and safety of combined
administration of IV and … ) were comparing the combined administration of IV and topical TXA …

Combined administration of IV and topical tranexamic acid is not superior to either individually in primary navigated TKA

EK Song, JK Seon, J Prakash, YJ Seol, YJ Park… - The Journal of …, 2017 - Elsevier
… of drug administration. We believe that additional amount of TXA administered in combined
… most effective mode of administration, we compared combined administration (topical and IV…

What is the ideal route of administration of tranexamic acid in TKA? A randomized controlled trial

SY Lee, S Chong, D Balasubramanian… - Clinical Orthopaedics …, 2017 - journals.lww.com
… Although our findings suggest that combined administration of tranexamic acid is not
more beneficial than IA use alone in patients undergoing primary unilateral TKA, it may be …

The efficacy and safety of combined administration of intravenous and intra‐articular tranexamic acid in total knee arthroplasty: an update meta‐analysis

T Ling, L Zhang, L Huang - Journal of Clinical Pharmacy and …, 2022 - Wiley Online Library
… This meta-analysis demonstrated that the combined administration of IV and IA TXA in TKA
is effective in reducing total blood loss, transfusion rate, postoperative haemoglobin drop, …

[HTML][HTML] The combined administration of systemic and topical tranexamic acid for total hip arthroplasty: Is it better than systemic?

D Gulabi, Y Yuce, KH Erkal, N Saglam… - Acta Orthopaedica et …, 2019 - Elsevier
… In conclusion, The combined administration of IV and topical TXA compared with IV alone
can decrease TBL and the number of blood transfusions required without increasing the risk of …

Perioperative combined administration of tranexamic acid and dexamethasone in total knee arthroplasty—benefit versus harm?

Y Yu, H Lin, Z Wu, P Xu, Z Lei - Medicine, 2019 - journals.lww.com
… The purpose of this study was to investigate the benefits and harm of combined administration
of tranexamic acid (TXA) and dexamethasone (Dexa) in total knee arthroplasty (TKA). …