Spinal cord injury and loss of cortical inhibition

B Benedetti, A Weidenhammer, M Reisinger… - International Journal of …, 2022 - mdpi.com
… Furthermore, some works have provided evidence against cortical disinhibition and in
favor of increased corticospinal inhibition when using paired-pulse TMS and comparing SCI …

Corticospinal function studied over time following incomplete spinal cord injury

HC Smith, G Savic, HL Frankel, PH Ellaway… - Spinal Cord, 2000 - nature.com
… We conclude that the weakened inhibition seen following iSCI is established within a few
days of the time of spinal cord trauma. We argue that reduced corticospinal inhibition may be a …

Corticospinal reorganization after spinal cord injury

M Oudega, MA Perez - The Journal of physiology, 2012 - Wiley Online Library
… Some experimental interventions were shown to facilitate corticospinal sprouting in the
spinal cord. Neutralization of the neurite outgrowth inhibitory protein Nogo-A leads to extensive …

Altered corticospinal function during movement preparation in humans with spinal cord injury

P Federico, MA Perez - The Journal of physiology, 2017 - Wiley Online Library
… Whether this ability is preserved after spinal cord injury (SCI) … of corticospinal axons and
short-interval intracortical inhibition in the … The magnitude of short-interval intracortical inhibition

Corticospinal inhibition investigated in relation to upper extremity motor function in cervical spinal cord injury

T Arora, J Liu, A Mohan, X Li, K O'laughlin… - Clinical …, 2024 - Elsevier
Corticospinal inhibitory mechanisms are relevant to functional recovery but remain poorly
understood after spinal cord injury (SCI). Post-injury characteristics of contralateral silent …

Short-interval intracortical inhibition with incomplete spinal cord injury

FD Roy, ET Zewdie, MA Gorassini - Clinical neurophysiology, 2011 - Elsevier
cord injury affects the excitability of circuits mediating short-interval intracortical inhibition
(SICI) of corticospinal … SICI was reduced in chronically injured subjects compared to uninjured …

Plasticity of corticospinal neural control after locomotor training in human spinal cord injury

M Knikou - Neural plasticity, 2012 - Wiley Online Library
… tract to exert an excitatory effect over Ia inhibitory interneurons [136]. In monkeys, … the
disynaptic inhibition of motor neurons evoked by corticospinal fibers and the disynaptic inhibition of …

Corticospinal circuit plasticity in motor rehabilitation from spinal cord injury

N Serradj, SF Agger, ER Hollis II - Neuroscience Letters, 2017 - Elsevier
corticospinal function after spinal cord injury is a significant challenge as the corticospinal
tract … Optogenetic inhibition of the motor cortex by stimulation of channelrhodopsin expressing …

Impaired crossed facilitation of the corticospinal pathway after cervical spinal cord injury

KL Bunday, MA Perez - Journal of neurophysiology, 2012 - journals.physiology.org
… To examine the mechanisms contributing to MEP crossed facilitation we examined short-interval
intracortical inhibition (SICI), interhemispheric inhibition (IHI), and motoneuronal …

From cortex to cord: motor circuit plasticity after spinal cord injury

AR Brown, M Martinez - Neural regeneration research, 2019 - journals.lww.com
… -induced plasticity of the corticospinal system that supports … of corticospinal circuit plasticity
after spinal cord injury and concentrate mainly on the hindlimb motor cortex, its corticospinal