… it is essential to identify all the outcomes of gene-editing activity in … vitro gene-editing system
in which a CRISPR-Cas complex … spectrum of gene-editing reaction outcomes utilizing Cas9 …

… a lack of articles studying gene editing in human … genes, as well as several studies on
germline gene correction (GGC). We will discuss observed issues regarding the genetic outcome …

… , which can occur in genes encoding structural proteins. Cryo-EM … that CRISPR-Cas systems
can drive phage genetic diversity, … of prokaryotic CRISPR-Cas adaptive immune systems’. …

… In addition, robust methods for predicting targeting outcomes (66) and achieving spatiotemporal
gene regulation (67) provide comprehensive strategies to reduce off-targets. Beyond …

… substantiate the use of CRISPR–Cas systems as genetic tools in bacteria and contribute to
our understanding the fundamental genetic and phenotypic outcomes of targeting bacterial …

… spacers from foreign DNA into the CRISPR array of the host. It … apparently different outcomes
of the CRISPR-Cas response … considering consequences of CRISPR-Cas systems action. …

… to visualize all genetic outcomes of the gene editing events in a reproducible and quantifiable
fashion. Due to the simplicity and straightforwardness of this reaction, gene editing events …

… In contrast, the application of CRISPR/Cas requires knowledge of gene sequences responsible
for the targeted trait. Currently, it cannot thus replace conventional breeding completely. …

… cytotoxic effects CRISPR-Cas targeting can induce. This study also features the different
genotypic outcomes that can result from same-gene-same-species targeting with CRISPR-Cas. …

… Currently, a variety of CRISPR/Cas-based therapeutics are being investigated in clinical …
are relevant to CRISPR/Cas-based gene therapies for monogenic human genetic diseases. …