… the action of IGFBPs and their proteases to influence IGF action: (1) IGFBP binding to IGFs
… receptors and (2) cleavage of the IGFBPs into fragments with lower affinity to IGFs allows for …

… significance of IGFBP proteases in cellular growth regulation. … Similar kallikreins such as
gamma nerve growth factor (NGF) … of the acid-activated IGFBP protease, cathepsin D, and its …

… The IGF system is a complex network comprised of two growth factors (IGF-I and -II), cell …
proteins (IGFBP-1 to IGFBP-6), IGFBP proteases as well as several other IGFBP-interacting …

… proteolysis has grown exponentially over the past five years, with the identification of several
new IGFBP proteases, a growing appreciation of the potential for IGF-independent actions …

… Although several well characterized serine proteases cleave IGFBP-4 or -5, the proteases …
IGFBP-5 protease degrades only IGFBP-5 and not other forms of IGFBPs, whereas proteases …

… of IGFBP-3, we assessed synovial fluid for IGFBP-3 protease activity (Fig. 4). Iodinated IGFBP…
fragments of IGFBP-3 of 22,20, and 17 kDa accounted for 60 ‘-t- 3% (mean t SD) of the total …

… IGFBPs (IGFBP-2 through -5). Synthesis is controlled by growth hormone and several other
growth factors. … IGFBPs including specific serine proteases that are produced for each form of …

… -4) are considered, respectively, as stimulators and inhibitors of follicular growth and … on
IGFBPs expression and IGFBP proteolytic degradation in the ovary, with a focus on the protease, …

… IGFBP-1 and increased IGFBP-3 protease activity. 16 There is no correlation between urinary
IGFBP-1 and serum creatinine. 16 Urinary IGFBP profiles and IGFBP protease activity have …

… contained an IGFBP-like domain and a separate serine protease domain. Since the protein
contained IGF binding and protease domains, it was proposed to be an IGFBP protease. In a …