Microsatellites are short tandem repeat DNA sequences of one to tetra base pairs distributed
throughout the human genome, both in coding and non-coding regions. Owing to their …

Microsatellite instability (MSI) is a clonal change in the number of repeated DNA nucleotide
units in microsatellites. It arises in tumors with deficient mismatch repair due to the …

Introduction Colorectal cancer is a heterogeneous tumor type with regard to molecular
pathogenesis and genetic instability. The majority of colorectal cancers display …

Microsatellite instability (MSI) is a molecular marker of a deficient mismatch repair (MMR)
system and occurs in approximately 15% of colorectal cancers (CRCs), more frequently in …

Colorectal cancer (CRC) is a heterogeneous disease that is caused by the interaction of
genetic and environmental factors. Although it is one of the most common cancers …

Purpose: Many studies have evaluated the role of high levels of microsatellite instability
(MSI) as a prognostic marker and predictor of the response to chemotherapy in colorectal …

Background Microsatellite instability (MSI) causes hereditary non-polyposis colorectal
cancer (HNPCC), and occurs in about 15 per cent of sporadic colorectal cancers. Although …

Aims: The genetic abnormality known as microsatellite instability (MSI), first identified in
colorectal cancer in 1993, has subsequently been recognised in other malignancies. These …

Colorectal cancer (CRC) incidence and mortality are constantly decreasing, but CRC still
remains the third most prevalent cancer and the third most common cause of cancer death in …

There is an increasing understanding of the roles that microsatellite instability (MSI) plays in
Lynch syndrome (by mutations) and sporadic (by mainly epigenetic changes) …