Intravenous administration of tranexamic acid effectively reduces blood loss in primary total knee arthroplasty in a 610‐patient consecutive case series

M Pitta, M Zawadsky, R Verstraete, A Rubinstein - Transfusion, 2016 - Wiley Online Library
BACKGROUND Tranexamic acid (TXA) has been reported to demonstrate efficacy in
reducing blood loss during arthroplasty procedures. STUDY DESIGN AND METHODS This …

The combined effect of administration of intravenous and topical tranexamic acid on blood loss and transfusion rate in total knee arthroplasty: combined tranexamic …

ZF Yuan, H Yin, WP Ma, DL Xing - Bone & joint research, 2016 - boneandjoint.org.uk
Objectives Tranexamic acid (TXA) is an antifibrinolytic agent used as a blood-sparing
technique in total knee arthroplasty (TKA), and is routinely administered by intravenous (IV) …

Use of intravenous tranexamic acid in total knee arthroplasty: a meta-analysis of randomized controlled trials

DJ Fu, C Chen, L Guo, L Yang - Chinese Journal of Traumatology, 2013 - mednexus.org
Objective: The effect of tranexamic acid (TA) on patients receiving total knee arthroplasty
(TKA) has been reported in many small clinical trials. But single trials are not sufficient …

[HTML][HTML] Safety and efficacy of intra-articular tranexamic acid injection without drainage on blood loss in total knee arthroplasty: a randomized clinical trial

C Wang, Z Sun, J Liu, JG Cao, Z Li - International journal of surgery, 2015 - Elsevier
Background Major blood loss is unavoidable after primary total knee arthroplasty (TKA). The
aim of this study was to determine if tranexamic acid (TXA) can reduce major blood loss …

One step closer to sparing total blood loss and transfusion rate in total knee arthroplasty: a meta-analysis of different methods of tranexamic acid administration

H Shemshaki, SMA Nourian, N Nourian… - Archives of orthopaedic …, 2015 - Springer
Background Tranexamic acid (TXA) in orthopedics has recently been gaining favor due to its
efficacy and ease of use, both in intravenous (IV) and intraarticular (IA) usage. However …

Multimodal peri-articular injection with tranexamic acid can reduce postoperative blood loss versus intravenous tranexamic acid in total knee arthroplasty: a …

H Peng, W Wang, J Lin, X Weng, W Qian… - Journal of Orthopaedic …, 2021 - Springer
Background Tranexamic acid (TXA) has shown significant reductions in blood loss and
transfusion rates in total knee arthroplasty (TKA). However, the optimal administration route …

Intra-articular injection of tranexamic acid reduce blood loss in cemented total knee arthroplasty

G Digas, I Koutsogiannis, G Meletiadis… - European journal of …, 2015 - Springer
The purpose of this study was to compare the efficacy of intravenous and topical tranexamic
acid (TXA) versus control group for reduction in blood loss following primary total knee …

Peri-articular tranexamic acid injection in total knee arthroplasty: a randomized controlled trial

P Pinsornsak, S Rojanavijitkul… - BMC musculoskeletal …, 2016 - Springer
Background Intravenous tranexamic acid (IV TXA) is one of the most effective agents in use
for reducing blood loss following total knee arthroplasty (TKA) but its safety regarding …

Comparison of topical and intravenous tranexamic acid for total knee replacement: a randomized double-blinded controlled study of effects on tranexamic acid levels …

KM Jules-Elysee, A Tseng, TP Sculco, LR Baaklini… - JBJS, 2019 - journals.lww.com
Background: Tranexamic acid (TXA) is an antifibrinolytic drug. Topical administration of TXA
during total knee arthroplasty (TKA) is favored for certain patients because of concerns …

The comparative efficacy and safety of topical and intravenous tranexamic acid for reducing perioperative blood loss in total knee arthroplasty-a randomized controlled …

J George, KK Eachempati, KN Subramanyam… - The Knee, 2018 - Elsevier
Abstract Background Total Knee Arthroplasty (TKA) can be associated with significant
perioperative blood loss and blood transfusions. This is a prospective randomised non …