The platform technology of fragment crystallizable (Fc) fusion, in which the Fc region of an
antibody is genetically linked to an active protein drug, is among the most successful of a …

High-throughput proteomics, based on the microarray platform, requires stable, highly
functional components that will yield a highly sensitive read-out of low abundance proteins …

Recombinant antibody fusion constructs with heterologous functional domains are a
promising approach to new therapeutic targeting strategies. However, expression of such …

Due mainly to their high level of affinity and specificity, therapeutic monoclonal antibodies
(mAbs) have been frequently selected as treatment for cancer, autoimmune or chronic …

In this review, we describe recent advances in antibody processing technology including:(1)
development of proprietary cell lines;(2) improved expression systems optimized by …

Over the past decade, there has been growing interest in the use of antibodies against
intracellular targets. This is currently achieved through recombinant expression of the single …

Background Antibodies have been a pillar of basic research, while their relevance in clinical
diagnostics and therapy is constantly growing. Consequently, the production of both …

Phage display libraries of human single-chain variable fragments (scFvs) are a reliable
source of fully human antibodies for scientific and clinical applications. Frequently, scFvs …

Antibodies, especially in the genetically engineered form, provide a powerful and diverse set
of reagents for the recognition of biological structures. Of key importance to those in the …

Background Due to their unique ability to bind their targets with high fidelity, antibodies are
used widely not only in biomedical research, but also in many clinical applications …