Alzheimer's disease and type 2 diabetes mellitus are distinct diseases with potential overlapping metabolic dysfunction upstream of observed cognitive decline

Y Chornenkyy, WX Wang, A Wei, PT Nelson - Brain Pathology, 2019 - Wiley Online Library
Alzheimer's disease (AD) and type 2 diabetes mellitus (T2 DM) are highly prevalent aging‐
related diseases associated with significant morbidity and mortality. Some findings in human …

An update on type 2 diabetes, vascular dementia and Alzheimer's disease

LG Exalto, RA Whitmer, LJ Kappele… - Experimental gerontology, 2012 - Elsevier
The risk of dementia is increased in people with type 2 diabetes mellitus (T2DM). This
review gives an update on the relation between T2DM and specific dementia subtypes–ie …

Relationship of type 2 diabetes to human brain pathology

JJ Pruzin, PT Nelson, EL Abner… - Neuropathology and …, 2018 - Wiley Online Library
Abstract Type 2 diabetes (T2D) and Alzheimer's disease (AD) are both highly prevalent
diseases worldwide, and each is associated with high‐morbidity and high‐mortality …

Altered glucose metabolism in Alzheimer's disease: role of mitochondrial dysfunction and oxidative stress

S Dewanjee, P Chakraborty, H Bhattacharya… - Free Radical Biology …, 2022 - Elsevier
Increasing evidence suggests that abnormal cerebral glucose metabolism is largely present
in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a …

Pathophysiology of cognitive dysfunction in older people with type 2 diabetes: vascular changes or neurodegeneration?

H Umegaki - Age and ageing, 2010 - academic.oup.com
Recent studies have revealed that type 2 diabetes mellitus (T2DM) is a risk factor for
cognitive dysfunction or dementia, especially those related to Alzheimer's disease (AD) …

Glucose metabolism and AD: evidence for a potential diabetes type 3

A González, C Calfío, M Churruca… - Alzheimer's research & …, 2022 - Springer
Background Alzheimer's disease is the most prevalent cause of dementia in the elderly.
Neuronal death and synaptic dysfunctions are considered the main hallmarks of this …

Type 2 diabetes as a risk factor for Alzheimer's disease: the confounders, interactions, and neuropathology associated with this relationship

NT Vagelatos, GD Eslick - Epidemiologic reviews, 2013 - academic.oup.com
We performed a systematic review and meta-analysis to explore whether type 2 diabetes
mellitus (T2DM) increases the risk of Alzheimer's disease (AD). We also reviewed …

Type 2 diabetes mellitus, dyslipidemia, and Alzheimer's disease

CM Carlsson - Journal of Alzheimer's disease, 2010 - content.iospress.com
The prevalence of Alzheimer's disease (AD) is increasing rapidly, heightening the
importance of finding effective preventive therapies for this devastating disease. Midlife …

A tale of two diseases: Exploring mechanisms linking diabetes mellitus with Alzheimer's disease

J Lynn, M Park, C Ogunwale… - Journal of …, 2022 - content.iospress.com
Dementias, including the type associated with Alzheimer's disease (AD), are on the rise
worldwide. Similarly, type 2 diabetes mellitus (T2DM) is one of the most prevalent chronic …

[HTML][HTML] Consequences of metabolic disruption in Alzheimer's disease pathology

JC Ryu, ER Zimmer, P Rosa-Neto, SO Yoon - Neurotherapeutics, 2019 - Elsevier
Alzheimer's disease (AD) is an irreversible, progressive disease that slowly destroys
cognitive function, such as thinking, remembering, and reasoning, to a level that one cannot …