[HTML][HTML] A prospective multicenter study of sirolimus for complicated vascular anomalies
Y Ji, S Chen, K Yang, J Zhou, X Zhang, X Jiang… - Journal of vascular …, 2021 - Elsevier
Abstract Objective Complicated vascular anomalies (VAs) can be intractable and
uncontrollable using conventional treatment and can result in lethal outcomes. We …
uncontrollable using conventional treatment and can result in lethal outcomes. We …
Sirolimus for the treatment of complicated vascular anomalies in children
AM Hammill, MS Wentzel, A Gupta… - Pediatric blood & …, 2011 - Wiley Online Library
Background Vascular anomalies comprise a diverse group of diagnoses. While infantile
hemangiomas are common, the majority of these conditions are quite rare and have not …
hemangiomas are common, the majority of these conditions are quite rare and have not …
[HTML][HTML] Preliminary results of the European multicentric phase III trial regarding sirolimus in slow-flow vascular malformations
BACKGROUND Slow-flow vascular malformations frequently harbor activating mutations in
the PI3K/AKT/mTOR cascade. Phase II trials pinpointed sirolimus effectiveness as a drug …
the PI3K/AKT/mTOR cascade. Phase II trials pinpointed sirolimus effectiveness as a drug …
Clinical delineation and natural history of the PIK3CA‐related overgrowth spectrum
KM Keppler‐Noreuil, JC Sapp… - American journal of …, 2014 - Wiley Online Library
Somatic mutations in the phosphatidylinositol/AKT/mTOR pathway cause segmental
overgrowth disorders. Diagnostic descriptors associated with PIK3CA mutations include …
overgrowth disorders. Diagnostic descriptors associated with PIK3CA mutations include …
New and emerging targeted therapies for vascular malformations
A Van Damme, E Seront, V Dekeuleneer… - American journal of …, 2020 - Springer
Vascular malformations are inborn errors of vascular morphogenesis and consist of
localized networks of abnormal blood and/or lymphatic vessels with weak endothelial cell …
localized networks of abnormal blood and/or lymphatic vessels with weak endothelial cell …
Vascular anomaly syndromes in the ISSVA classification system: imaging findings and role of interventional radiology in management
Vascular anomalies encompass a spectrum of tumors and malformations that can cause
significant morbidity and mortality in children and adults. Use of the International Society for …
significant morbidity and mortality in children and adults. Use of the International Society for …
Complex vascular anomalies
RG Azizkhan - Pediatric Surgery International, 2013 - Springer
The classification system for vascular anomalies now used by experts worldwide comprises
two distinct disease entities that differ in their biologic and pathologic features: vascular …
two distinct disease entities that differ in their biologic and pathologic features: vascular …
[HTML][HTML] Sirolimus in the treatment of vascular anomalies
P Triana, M Dore, VN Cerezo… - European Journal of …, 2017 - thieme-connect.com
Aim of the Study mTOR inhibitors are showing promising results in the management of
vascular anomalies. Although current controlled trials remain to be completed, many …
vascular anomalies. Although current controlled trials remain to be completed, many …
[HTML][HTML] Constitutively active PIK3CA mutations are expressed by lymphatic and vascular endothelial cells in capillary lymphatic venous malformation
TD Le Cras, J Goines, N Lakes, P Pastura, AM Hammill… - Angiogenesis, 2020 - Springer
Capillary lymphatic venous malformations (CLVM) are complex vascular anomalies
characterized by aberrant and enlarged lymphatic and blood vessels. CLVM appear during …
characterized by aberrant and enlarged lymphatic and blood vessels. CLVM appear during …
Single-center experience with sirolimus therapy for vascular malformations
S Yesil, HG Tanyildiz, C Bozkurt… - Pediatric hematology …, 2016 - Taylor & Francis
Vascular malformations (VMs) are described as congenital malformations of the vasculature
derived from capillaries, veins, lymphatic vessels, arteries, or a combination of these …
derived from capillaries, veins, lymphatic vessels, arteries, or a combination of these …