Abstract Objective Complicated vascular anomalies (VAs) can be intractable and
uncontrollable using conventional treatment and can result in lethal outcomes. We …

Background Vascular anomalies comprise a diverse group of diagnoses. While infantile
hemangiomas are common, the majority of these conditions are quite rare and have not …

BACKGROUND Slow-flow vascular malformations frequently harbor activating mutations in
the PI3K/AKT/mTOR cascade. Phase II trials pinpointed sirolimus effectiveness as a drug …

Somatic mutations in the phosphatidylinositol/AKT/mTOR pathway cause segmental
overgrowth disorders. Diagnostic descriptors associated with PIK3CA mutations include …

Vascular malformations are inborn errors of vascular morphogenesis and consist of
localized networks of abnormal blood and/or lymphatic vessels with weak endothelial cell …

Vascular anomalies encompass a spectrum of tumors and malformations that can cause
significant morbidity and mortality in children and adults. Use of the International Society for …

The classification system for vascular anomalies now used by experts worldwide comprises
two distinct disease entities that differ in their biologic and pathologic features: vascular …

Aim of the Study mTOR inhibitors are showing promising results in the management of
vascular anomalies. Although current controlled trials remain to be completed, many …

Capillary lymphatic venous malformations (CLVM) are complex vascular anomalies
characterized by aberrant and enlarged lymphatic and blood vessels. CLVM appear during …

Vascular malformations (VMs) are described as congenital malformations of the vasculature
derived from capillaries, veins, lymphatic vessels, arteries, or a combination of these …