Single-chain antibody fragments: Purification methodologies
LP Malpiedi, CA Diaz, BB Nerli, A Pessoa Jr - Process Biochemistry, 2013 - Elsevier
At present, single-chain variable fragments (scFv) of antibodies are considered one of the
most important tools in human therapies. Wide applications of antibodies are being …
most important tools in human therapies. Wide applications of antibodies are being …
Characterization of single chain antibody targets through yeast two hybrid
Background Due to their unique ability to bind their targets with high fidelity, antibodies are
used widely not only in biomedical research, but also in many clinical applications …
used widely not only in biomedical research, but also in many clinical applications …
New protein engineering approaches to multivalent and bispecific antibody fragments
A Plückthun, P Pack - Immunotechnology, 1997 - Elsevier
Multivalency is one of the hallmarks of antibodies, by which enormous gains in functional
affinity, and thereby improved performance in vivo and in a variety of in vitro assays are …
affinity, and thereby improved performance in vivo and in a variety of in vitro assays are …
Engineered antibody fragments and the rise of single domains
P Holliger, PJ Hudson - Nature biotechnology, 2005 - nature.com
With 18 monoclonal antibody (mAb) products currently on the market and more than 100 in
clinical trials, it is clear that engineered antibodies have come of age as biopharmaceuticals …
clinical trials, it is clear that engineered antibodies have come of age as biopharmaceuticals …
Production of Therapeutic Single-Chain Variable Fragments (ScFv) in Pichia pastoris
L Montoliu-Gaya, S Villegas - Therapeutic Antibodies: Methods and …, 2022 - Springer
The interest in the use of monoclonal antibodies as therapeutic molecules has raised in the
recent years. Due to their high affinity and specificity towards other biological molecules …
recent years. Due to their high affinity and specificity towards other biological molecules …
Cell-free synthesis meets antibody production: a review
M Stech, S Kubick - Antibodies, 2015 - mdpi.com
Engineered antibodies are key players in therapy, diagnostics and research. In addition to
full size immunoglobulin gamma (IgG) molecules, smaller formats of recombinant …
full size immunoglobulin gamma (IgG) molecules, smaller formats of recombinant …
Development trends for therapeutic antibody fragments
AL Nelson, JM Reichert - Nature biotechnology, 2009 - nature.com
Development trends for therapeutic antibody fragments | Nature Biotechnology Skip to main
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Recombinant antibody production evolves into multiple options aimed at yielding reagents suitable for application-specific needs
A De Marco - Microbial cell factories, 2015 - Springer
Background Antibodies have been a pillar of basic research, while their relevance in clinical
diagnostics and therapy is constantly growing. Consequently, the production of both …
diagnostics and therapy is constantly growing. Consequently, the production of both …
Applications of single-chain variable fragment antibodies in therapeutics and diagnostics
NE Weisser, JC Hall - Biotechnology advances, 2009 - Elsevier
Antibodies (Abs) are some of the most powerful tools in therapy and diagnostics and are
currently one of the fastest growing classes of therapeutic molecules. Recombinant antibody …
currently one of the fastest growing classes of therapeutic molecules. Recombinant antibody …
Bioengineering of antibody fragments: challenges and opportunities
S Pirkalkhoran, WR Grabowska, HH Kashkoli… - Bioengineering, 2023 - mdpi.com
Antibody fragments are used in the clinic as important therapeutic proteins for treatment of
indications where better tissue penetration and less immunogenic molecules are needed …
indications where better tissue penetration and less immunogenic molecules are needed …