The major pathways of DNA double-strand break (DSB) repair are crucial for maintaining
genomic stability. However, if deployed in an inappropriate cellular context, these same …

DNA double-strand breaks (DSBs) are highly toxic lesions that can drive genetic instability.
To preserve genome integrity, organisms have evolved several DSB repair mechanisms, of …

DNA double-strand breaks (DSBs) are cytotoxic lesions that threaten genomic integrity.
Failure to repair a DSB has deleterious consequences, including genomic instability and cell …

DNA double-strand breaks (DSBs) arise in cells from endogenous and exogenous attacks
on the DNA backbone, but also as a direct consequence of replication failures. Proper repair …

DNA double-strand breaks (DSBs) arise regularly in cells and when left unrepaired cause
senescence or cell death. Homologous recombination (HR) and nonhomologous end …

DNA DSBs (double-strand breaks) are a significant threat to the viability of a normal cell,
since they can result in loss of genetic material if mitosis or replication is attempted in their …

Repair of DNA double strand breaks (DSBs) plays a critical role in the maintenance of the
genome. DSB arise frequently as a consequence of replication fork stalling and also due to …

DNA double-strand breaks (DSBs) are dangerous lesions that can lead to potentially
oncogenic genomic rearrangements or cell death. The two major pathways for repair of …

Proper repair of DNA double strand breaks (DSBs) is vital for the preservation of genomic
integrity. There are two main pathways that repair DSBs, Homologous recombination (HR) …

Preserving the integrity of the DNA double helix is crucial for the maintenance of genomic
stability. Therefore, DNA double‐strand breaks represent a serious threat to cells. In this …