We review evidence of determinants contributing to increased opioid-related mortality in the
United States and Canada between 1990 and 2013. We identified 17 determinants of opioid …

Importance Opioid prescribing and overdose are leading public health problems in North
America, yet the precise public health burden has not been quantified. Objective To examine …

Methods: We reviewed all public-facing opioid-related surveillance or epidemiological
reports published by provincial and territorial ministries of health and chief coroners' or …

Conclusion In summary, we found large regional variations in opioid prescribing and
outcomes and a strong association between regions with high opioid prescription utilization …

Importance As the opioid epidemic evolves, it is vital to identify changes in the geographical
distribution of opioid-related deaths, and the specific opioids to which those deaths are …

Over the last two decades, opioid-related mortality rates have increased dramatically to
become a serious public health concern in the United States. Opioid-related mortality has …

Background: Recent research on the US opioid epidemic has focused on the white or total
population and has largely been limited to data after 1999. However, understanding racial …

Background The impact of the prescription opioid public health crisis has been illustrated by
the dramatic increase in opioid-related deaths in North America. We aimed to identify …

Abstract Background North America has been experiencing a persistent epidemic of opioid-
related overdose mortality, which has increasingly been driven by fatalities from illicit, toxic …

Background: Prescription opioid–related overdose deaths increased sharply during 1999–
2010 in the United States in parallel with increased opioid prescribing. CDC assessed …