Dual inhibition of CSF1R and MAPK pathways using supramolecular nanoparticles enhances macrophage immunotherapy

A Ramesh, A Brouillard, S Kumar, D Nandi, A Kulkarni - Biomaterials, 2020 - Elsevier
Among the numerous immune interactions, or lack-thereof, that occur during cancer
progression, tumor-associated macrophages (TAMs)–cancer cell interactions have been …

Research trends in pharmacological modulation of tumor‐associated macrophages

N Wang, S Wang, X Wang, Y Zheng… - Clinical and …, 2021 - Wiley Online Library
As one of the most abundant immune cell populations in the tumor microenvironment (TME),
tumor‐associated macrophages (TAMs) play important roles in multiple solid malignancies …

[HTML][HTML] Harnessing and enhancing macrophage phagocytosis for cancer therapy

S Chen, SWT Lai, CE Brown, M Feng - Frontiers in Immunology, 2021 - frontiersin.org
Cancer immunotherapy has revolutionized the paradigm for the clinical management of
cancer. While FDA-approved cancer immunotherapies thus far mainly exploit the adaptive …

[HTML][HTML] Tumor-associated macrophages: A promising target for a cancer immunotherapeutic strategy

SY Zhang, XY Song, Y Li, LL Ye, Q Zhou… - Pharmacological …, 2020 - Elsevier
Macrophages, a type of myeloid immune cell, play essential roles in fighting against
pathogenic invasion and activating T cell-mediated adaptive immune responses. As a major …

Precise delivery of nanomedicines to M2 macrophages by combining “Eat Me/Don't Eat Me” signals and its anticancer application

Y Tang, Z Tang, P Li, K Tang, Z Ma, Y Wang, X Wang… - ACS …, 2021 - ACS Publications
Targeted delivery of nanomedicines to M2 tumor-associated macrophages (TAMs) has been
proposed to reduce tumor promotion and enhance the efficacy of anticancer therapy …

Tumor-Microenvironment-Activatable Nanoparticle Mediating Immunogene Therapy and M2 Macrophage-Targeted Inhibitor for Synergistic Cancer Immunotherapy

Y Hu, W Nie, L Lyu, X Zhang, W Wang, Y Zhang, S He… - ACS …, 2024 - ACS Publications
Immunotherapy has achieved prominent clinical efficacy in combating cancer and has
recently become a mainstream treatment strategy. However, achieving broad efficacy with a …

Reprogramming tumor-associated macrophages by nanoparticle-based reactive oxygen species photogeneration

C Shi, T Liu, Z Guo, R Zhuang, X Zhang, X Chen - Nano letters, 2018 - ACS Publications
Without coordinated strategies to mitigate the immunosuppressive nature of the tumor
microenvironment, cancer immunotherapy generally offers limited clinical benefit for …

Macrophage cell membrane‐cloaked nanoplatforms for biomedical applications

J Lopes, D Lopes, M Pereira‐Silva, D Peixoto… - Small …, 2022 - Wiley Online Library
Biomimetic approaches utilize natural cell membrane‐derived nanovesicles to camouflage
nanoparticles to circumvent some limitations of nanoscale materials. This emergent cell …

Tumor Associated Macrophages and TAMs‐Based Anti‐Tumor Nanomedicines

Y Cheng, S Song, P Wu, B Lyu, M Qin… - Advanced …, 2021 - Wiley Online Library
As an important part of tumor microenvironment, tumor associated macrophages (TAMs)
play a vital role in the occurrence, development, invasion, and metastasis of many malignant …

Engineering endogenous tumor‐associated macrophage‐targeted biomimetic nano‐RBC to Reprogram tumor immunosuppressive microenvironment for enhanced …

Y Wang, J Yu, Z Luo, Q Shi, G Liu, F Wu… - Advanced …, 2021 - Wiley Online Library
Immunotherapy has shown encouraging results in various cancers, but the response rates
are relatively low due to the complex tumor immunosuppressive microenvironment (TIME) …