Restoring corticospinal function after spinal cord injury is a significant challenge as the
corticospinal tract elicits no substantive, spontaneous regeneration, and its interruption …

Spinal cord injury is associated with chronic sensorimotor deficits due to the interruption of
ascending and descending tracts between the brain and spinal cord. Functional recovery …

Spinal cord injury (SCI) is a devastating condition that affects approximately 294,000 people
in the USA and several millions worldwide. The corticospinal motor circuitry plays a major …

Spinal lesions substantially impair ambulation, occur generally in young and otherwise
healthy individuals, and result in devastating effects on quality of life. Restoration of …

The plasticity of sensorimotor systems in mammals underlies the capacity for motor learning
as well as the ability to relearn following injury. Spinal cord injury, which both deprives …

Injury to the mature motor system drives significant spontaneous axonal sprouting instead of
axon regeneration. Knowing the circuit-level determinants of axonal sprouting is important …

The corticospinal tract (CST) is a major descending pathway contributing to the control of
voluntary movement in mammals. During the last decades anatomical and …

Stroke causes long-term disability, and rehabilitative training is commonly used to improve
the consecutive functional recovery. Following brain damage, surviving neurons undergo …

The corticospinal tract is an important target for motor recovery after spinal cord injury (SCI)
in animals and humans [1–5]. Voluntary motor output depends on the efficacy of synapses …

The sudden loss of movement after spinal cord injury (SCI) is life-changing and is a major
impetus to study spinal cord motor system plasticity and devise novel repair strategies. This …