[HTML][HTML] Viral Nucleases
Z Wang, RJ Geraghty - Viruses, 2023 - mdpi.com
Nucleases are ubiquitous hydrolytic enzymes that cleave phosphodiester bond of DNA
(DNases), RNA (RNases), or protein-RNA/DNA (phosphodiesterases), within the strand …
(DNases), RNA (RNases), or protein-RNA/DNA (phosphodiesterases), within the strand …
[PDF][PDF] Viral Nucleases. Viruses 2023, 15, 740
Z Wang, RJ Geraghty - 2023 - pdfs.semanticscholar.org
Nucleases are ubiquitous hydrolytic enzymes that cleave phosphodiester bond of DNA
(DNases), RNA (RNases), or protein-RNA/DNA (phosphodiesterases), within the strand …
(DNases), RNA (RNases), or protein-RNA/DNA (phosphodiesterases), within the strand …
Characterization and Inhibition of Viral Nuclease Enzymes
B Todd, G John - 2021 - era.library.ualberta.ca
Viral infection accounts for significant morbidity, mortality, and economic loss worldwide. At
no time in modern history has this been more apparent than it is now given the current …
no time in modern history has this been more apparent than it is now given the current …
[PDF][PDF] Identifying Structural Features of Nucleotide Analogues to Overcome SARS-CoV-2 Exonuclease Activity. Viruses 2022, 14, 1413
X Wang, C Tao, I Morozova, S Kalachikov, X Li… - 2022 - academia.edu
With the recent global spread of new SARS-CoV-2 variants, there remains an urgent need to
develop effective and variant-resistant oral drugs. Recently, we reported in vitro results …
develop effective and variant-resistant oral drugs. Recently, we reported in vitro results …
Substrate specificity and kinetics of RNA hydrolysis by SARS-CoV-2 NSP10/14 exonuclease
TL Dangerfield, KA Johnson - ACS Bio & Med Chem Au, 2022 - ACS Publications
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the virus that causes
COVID-19, continues to evolve resistance to vaccines and existing antiviral therapies at an …
COVID-19, continues to evolve resistance to vaccines and existing antiviral therapies at an …
[HTML][HTML] Coronavirus RNA proofreading: molecular basis and therapeutic targeting
F Robson, KS Khan, TK Le, C Paris, S Demirbag… - Molecular cell, 2020 - cell.com
Summary The coronavirus disease 2019 (COVID-19) that is wreaking havoc on worldwide
public health and economies has heightened awareness about the lack of effective antiviral …
public health and economies has heightened awareness about the lack of effective antiviral …
[HTML][HTML] Combination of antiviral drugs inhibits SARS-CoV-2 polymerase and exonuclease and demonstrates COVID-19 therapeutic potential in viral cell culture
X Wang, CQ Sacramento, S Jockusch… - Communications …, 2022 - nature.com
SARS-CoV-2 has an exonuclease-based proofreader, which removes nucleotide inhibitors
such as Remdesivir that are incorporated into the viral RNA during replication, reducing the …
such as Remdesivir that are incorporated into the viral RNA during replication, reducing the …
[HTML][HTML] Identifying structural features of nucleotide analogues to overcome SARS-CoV-2 exonuclease activity
X Wang, C Tao, I Morozova, S Kalachikov, X Li… - Viruses, 2022 - mdpi.com
With the recent global spread of new SARS-CoV-2 variants, there remains an urgent need to
develop effective and variant-resistant oral drugs. Recently, we reported in vitro results …
develop effective and variant-resistant oral drugs. Recently, we reported in vitro results …
Coronavirus genomic nsp14‐ExoN, structure, role, mechanism, and potential application as a drug target
M Tahir - Journal of Medical Virology, 2021 - Wiley Online Library
The recent coronavirus disease 2019 (COVID‐19), causing a global pandemic with
devastating effects on healthcare and social‐economic systems, has no special antiviral …
devastating effects on healthcare and social‐economic systems, has no special antiviral …
[HTML][HTML] Combination of antiviral drugs to inhibit SARS-CoV-2 polymerase and exonuclease as potential COVID-19 therapeutics
X Wang, CQ Sacramento, S Jockusch, OA Chaves… - bioRxiv, 2021 - ncbi.nlm.nih.gov
SARS-CoV-2 has an exonuclease-based proofreader, which removes nucleotide inhibitors
such as Remdesivir that are incorporated into the viral RNA during replication, reducing the …
such as Remdesivir that are incorporated into the viral RNA during replication, reducing the …