The efficacy of macrophage-mediated inflammatory response relies on the coordinated
expression of key factors, which expression is finely regulated at both transcriptional and …

Significance: MicroRNAs (miRNAs) control cellular gene expression via primarily binding to
3′ or 5′ untranslated region of the target transcript leading to translational repression or …

Macrophages dictate both initiation and resolution of inflammation. During acute
inflammation classically activated macrophages (M1) predominate, and during the …

Inflammatory M1 spectrum macrophages protect from infection but can cause inflammatory
disease and tissue damage, whereas alternatively activated/M2 spectrum macrophages …

microRNAs are small noncoding RNAs that regulate protein-coding genes via
posttranscriptional repression. Most protein-coding genes are subjected to microRNA …

Macrophages are highly plastic cells with the ability to differentiate into both M1-and M2-
polarized phenotypes. As a distinct M2-polarized population, tumour-associated …

Macrophage polarization is a process through which macrophages attain unique functional
features as a response to certain stimuli from their niche. Lipopolysaccharide and Th1 …

MicroRNAs (miRNAs) are important regulators of gene expression in the immune system. In
a few short years, their mechanism of action has been described in various cell lineages …

Mucosal surface epithelial cells are equipped with several defense mechanisms that guard
against pathogens. Recent studies indicate that microRNAs (miRNAs) mediate post …

Macrophages are known to have an impact in cytokine signaling in the myriad of organs in
which they reside and are classically known to be either pro-inflammatory (M1), anti …