As healthcare delivery in the USA transforms into a model that at its core requires value-
based considerations, ischemic stroke is confronted by intersecting forces. Modern …

Background Limited efficacy of IV recombinant tissue plasminogen activator (rt-PA) for large
vessel occlusions (LVO) raises doubts about its utility prior to endovascular therapy …

Background and purpose The present study was conducted with the objective of evaluating
the safety of primary mechanical thrombectomy (MT) in patients with large vessel occlusion …

Background and Purpose—Intracranial mechanical thrombectomy is a therapeutic option for
acute ischemic stroke patients failing intravenous tissue plasminogen activator (IV tPA). We …

BACKGROUND AND PURPOSE: It is unclear whether the costs and risks of mechanical
therapies make them cost-effective. We examined whether interventions such as mechanical …

Intravenous thrombolytic therapy is the only proven treatment for acute ischemic stroke, but
its use is limited by a brief time window of up to 4.5 hours after the onset of symptoms1 and a …

Background and purpose We compared outcomes between endovascular (EV) therapy and
intravenous (IV) thrombolysis in large vessel strokes. Methods 223 patients who had …

Background and Purpose—Intravenous thrombolysis (IVT) within 4.5 hours of symptom
onset is currently recommended before mechanical thrombectomy (MT). We compared …

Goyal et al Implementation Challenges of Endovascular Therapy 549 intravenous r-tPA has
limited efficacy for early recanalization in the context of large vessel occlusion (31% showed …

Background and Purpose—Although current guidelines advocate pretreatment with
intravenous thrombolysis (IVT) in all eligible patients with acute ischemic stroke with large …