Overgrowth syndromes are characterized by global or localized disproportionate growth
associated with other anomalies, including vascular malformations and neurological and/or …

Congenital lipomatous asymmetric overgrowth of the trunk, lymphatic, capillary, venous, and
combined‐type vascular malformations, epidermal nevi, skeletal and spinal anomalies …

Congenital lipomatous overgrowth with vascular, epidermal, and skeletal anomalies
(CLOVES) is a sporadically occurring, nonhereditary disorder characterized by asymmetric …

CLOVES syndrome (congenital lipomatous overgrowth, vascular malformations, epidermal
naevi, scoliosis/skeletal and spinal syndrome) is a genetic disorder that results from somatic …

PIK3CA-related overgrowth spectrum (PROS) is an umbrella term referring to various clinical
entities, which share the same pathogenetic mechanism. These conditions are caused by …

Somatic mutations in the phosphatidylinositol/AKT/mTOR pathway cause segmental
overgrowth disorders. Diagnostic descriptors associated with PIK3CA mutations include …

Abstract Klippel–Trenaunay syndrome (KTS), originally described as a triad of cutaneous
capillary malformation, bone and soft‐tissue hypertrophy, as well as venous and lymphatic …

Somatic activating mutations in the phosphatidylinositol‐3‐kinase/AKT/mTOR pathway
underlie heterogeneous segmental overgrowth phenotypes. Because of the extreme …

PIK3CA-related overgrowth spectrum (PROS) encompasses a range of clinical findings in
which the core features are congenital or early-childhood onset of segmental/focal …

Somatic mutations in PIK3CA cause many overgrowth syndromes that have been recently
coined the “PIK3CA‐Related Overgrowth Spectrum.” Here, we present seven molecularly …