Human Synthetic Calcitonin Gene-Related Peptide Inhibits Bone Resorption in Vitro

SM D'SOUZA, I MacIntyre, SI Girgis, GR Mundy - Endocrinology, 1986 - academic.oup.com
The calcitonin gene-related peptide (CGRP) is a pepticle which normally circulates. It is
encoded by the calcitonin gene, whose precise function is unknown. Since it has recently …

Human calcitonin gene-related peptide possesses weak inhibitory potency of bone resorptionin vitro

I Yamamoto, N Kitamura, J Aoki, C Shigeno… - Calcified tissue …, 1986 - Springer
Synthetic human calcitonin gene-related peptide (CGRP) was examined for the action on
the bone in vitro. Human CGRP inhibited bone resorption stimulated by both human …

Calcitonin gene-related peptide inhibits osteoclastic bone resorption: a comparative study

M Zaidi, K Fuller, PJR Bevis, RE GainesDas… - Calcified tissue …, 1987 - Springer
Besides the calcitonin (CT) precursor, the calcitonin gene also encodes another peptide—
calcitonin gene-related peptide (CGRP). We have previously reported that CGRP lowers …

A direct action of human calcitonin gene-related peptide on isolated osteoclasts

M Zaidi, TJ Chambers, REG Das… - Journal of …, 1987 - joe.bioscientifica.com
The calcitonin gene encodes a small family of peptides: calcitonin, calcitonin gene-related
peptide (CGRP) and katacalcin. Whereas calcitonin is concerned with skeletal maintenance …

Effects of peptides from the calcitonin genes on bone and bone cells

M Zaidi, PJR Bevis, JL Beacham… - Quarterly Journal of …, 1988 - Wiley Online Library
The calcitonin‐calcitonin gene‐related peptide (CGRP) gene complex encodes a family of
novel peptides‐calcitonin, CGRP and katacalcin. Whereas calcitonin is a circulating …

Structure-activity relationship of human calcitonin-gene-related peptide

M Zaidi, SD Brain, JR Tippins, V Di Marzo… - Biochemical …, 1990 - portlandpress.com
The calcitonin-calcitonin-gene-related peptide (CGRP) gene complex encodes a small
family of peptides: calcitonin, CGRP and katacalcin. Calcitonin is a circulating hormone that …

Effects of calcitonin gene-related peptide on bone turnover in ovariectomized rats

K Valentijn, AP Gutow, N Troiano, C Gundberg… - Bone, 1997 - Elsevier
Calcitonin gene-related peptide (CGRP) is a neuropeptide abundantly concentrated in
sensory nerve endings innervating bone metaphysis and periosteum, which indicates that it …

Structure‐activity relationships in calcitonin gene‐related peptide: Cyclic AMP response in a preosteoblast cell line (ks‐4)

D Thiebaud, T Akatsu, T Yamashita… - Journal of Bone and …, 1991 - Wiley Online Library
Synthetic analogs of chicken and human CGRP were used to define structure‐function
relationships in a murine osteoblast precursor cell line, KS‐4, that exhibits a substantial …

Evaluation of the in Vivo and in Vitro Calcium Regulating Actions of Noncalcitonin Peptides Produced via Calcitonin Gene Expression

BA ROOS, JANA FISCHER, W PIGNAT… - …, 1986 - academic.oup.com
Recent studies of rat and human calcitonin (CT) gene expression have uncovered a
diversity of secretory peptides. Here we report the results of testing two such non-CT …

The osteogenic stimulating effect of neuroactive calcitonin gene-related peptide

GW Bernard, C Shih - Peptides, 1990 - Elsevier
Abstract Silverman and Kruger (Somatosens. Res. 5 (2): 157–175; 1987) reported that
sensory nerve fibers of the dental pulp secrete calcitonin gene-related peptide (CGRP) …