An update on type 2 diabetes mellitus as a risk factor for dementia

W Li, E Huang - Journal of Alzheimer's Disease, 2016 - content.iospress.com
With the rapidly expanding evidence on brain structural and functional changes in type 2
diabetes mellitus (T2DM) patients, there is an increasing need to update our understanding …

Type 2 diabetes as a risk factor for cognitive impairment: current insights

H Umegaki - Clinical interventions in aging, 2014 - Taylor & Francis
Type 2 diabetes mellitus (T2DM) is a risk factor for cognitive dysfunction and dementia in the
elderly. T2DM has been thought to be associated with vascular diseases, eventually leading …

Relationship of type 2 diabetes to human brain pathology

JJ Pruzin, PT Nelson, EL Abner… - Neuropathology and …, 2018 - Wiley Online Library
Abstract Type 2 diabetes (T2D) and Alzheimer's disease (AD) are both highly prevalent
diseases worldwide, and each is associated with high‐morbidity and high‐mortality …

Type 2 diabetes and cognitive impairment: linking mechanisms

JA Luchsinger - Journal of Alzheimer's Disease, 2012 - content.iospress.com
This manuscript provides a brief review of current concepts in the mechanisms potentially
linking type-2-diabetes (T2D) with cognitive impairment. Existing epidemiologic studies …

Physiological mechanisms inherent to diabetes involved in the development of dementia: Alzheimer's disease

H Mohamed-Mohamed, V García-Morales… - Neurology …, 2023 - mdpi.com
Type 2 diabetes mellitus (T2D) is a metabolic disease reaching pandemic levels worldwide.
In parallel, Alzheimer's disease (AD) and vascular dementia (VaD) are the two leading …

Pathophysiological mechanisms linking type 2 diabetes and dementia: review of evidence from clinical, translational and epidemiological research

OY Bello-Chavolla, NE Antonio-Villa… - Current diabetes …, 2019 - ingentaconnect.com
Background: Type 2 diabetes represents an increasing health burden world-wide and its
prevalence in particularly higher in elderly population. Consistent epidemiological evidence …

An update on type 2 diabetes, vascular dementia and Alzheimer's disease

LG Exalto, RA Whitmer, LJ Kappele… - Experimental gerontology, 2012 - Elsevier
The risk of dementia is increased in people with type 2 diabetes mellitus (T2DM). This
review gives an update on the relation between T2DM and specific dementia subtypes–ie …

Alzheimer's disease and type 2 diabetes mellitus are distinct diseases with potential overlapping metabolic dysfunction upstream of observed cognitive decline

Y Chornenkyy, WX Wang, A Wei, PT Nelson - Brain Pathology, 2019 - Wiley Online Library
Alzheimer's disease (AD) and type 2 diabetes mellitus (T2 DM) are highly prevalent aging‐
related diseases associated with significant morbidity and mortality. Some findings in human …

Diabetes mellitus: a path to amnesia, personality, and behavior change

R Ahmad, K Chowdhury, S Kumar, M Irfan, GS Reddy… - Biology, 2022 - mdpi.com
Simple Summary Diabetes Mellitus (DM) is a metabolic disorder resulting from a disturbance
of insulin secretion, action, or both. Hyperglycemia and overproduction of superoxide induce …

Type 2 diabetes mellitus and biomarkers of neurodegeneration

C Moran, R Beare, TG Phan, DG Bruce, ML Callisaya… - Neurology, 2015 - AAN Enterprises
Objective: Our objective was to investigate whether type 2 diabetes mellitus (T2DM)
influences neurodegeneration in a manner similar to Alzheimer disease (AD), by promoting …