BACKGROUND AND PURPOSE: Diffusion tensor imaging (DTI) allows direct visualization
and volumetric analysis of the corticospinal tract (CST). The purpose of this study was to …

ABSTRACT Background and Purpose: Diffusion tensor imaging (DTI) was used as a
noninvasive method to evaluate the anatomy of the corticospinal tract (CST) and the pattern …

OBJECTIVE: Aim of present study was to evaluate changes in diffusion tensor imaging (DTI)
parameters in the whole brain of 28 patients with amyotrophic lateral sclerosis (ALS) …

Background Amyotrophic lateral sclerosis (ALS) is characterized by pronounced clinical
heterogeneity in terms of onset and disease progression. Widespread changes in white …

Objective: The potential of magnetic resonance imaging (MRI) as a technical biomarker for
cerebral microstructural alterations in neurodegenerative diseases is under investigation. In …

In this study, we investigated whether diffusion tensor MRI (DTI) could detect progressive
corticospinal tract degeneration in amyotrophic lateral sclerosis (ALS) and whether changes …

This work evaluates the potential in diagnostic application of a new advanced neuroimaging
method, which delineates the profile of tissue properties along the corticospinal tract (CST) …

BACKGROUND AND PURPOSE: ALS leads to macrostructural (ie, cortical atrophy and
hyperintensities along the corticospinal tract) and microstructural (ie, gray matter intrinsic …

Therapeutic development in amyotrophic lateral sclerosis (ALS) is hampered by the lack of
suitable biomarkers that might be sensitive to spatial and temporal patterns of …

Amyotrophic lateral sclerosis is characterized by degeneration of upper and lower motor
neurons. Diffusion tensor imaging (DTI) indexes obtained along the corticospinal tracts …