Highly Efficient Biosynthesis of Protocatechuic Acid via Recombinant Pseudomonas putida KT2440

J Li, J Fu, C Yue, Y Shang, BC Ye - Journal of Agricultural and …, 2023 - ACS Publications
Owing to their physiological activities, plant-derived phenolic acids, such as protocatechuic
acid (PCA), have extensive applications and market prospects. However, traditional …

Metabolic engineering of Pseudomonas putida KT2440 for high-yield production of protocatechuic acid

J Li, BC Ye - Bioresource Technology, 2021 - Elsevier
Protocatechuic acid (PCA) has been widely utilized in conventional pharmaceutical,
cosmetic and functional food industries. Currently, chemical synthesis and solvent extraction …

Biological Valorization of Lignin-Derived Aromatics in Hydrolysate to Protocatechuic Acid by Engineered Pseudomonas putida KT2440

X Jin, X Li, L Zou, Z Zheng, J Ouyang - Molecules, 2024 - mdpi.com
Alongside fermentable sugars, weak acids, and furan derivatives, lignocellulosic
hydrolysates contain non-negligible amounts of lignin-derived aromatic compounds. The …

Protocatechuate overproduction by Corynebacterium glutamicum via simultaneous engineering of native and heterologous biosynthetic pathways

T Kogure, M Suda, K Hiraga, M Inui - Metabolic engineering, 2021 - Elsevier
Abstract Protocatechuic acid (3, 4-dihydroxybenzoic acid, PCA) is a natural bioactive
phenolic acid potentially valuable as a pharmaceutical raw material owing to its diverse …

Comparing E. coli mono-cultures and co-cultures for biosynthesis of protocatechuic acid and hydroquinone

X Guo, X Wang, T Chen, Y Lu, H Zhang - Biochemical Engineering Journal, 2020 - Elsevier
Protocatechuic acid (PCA) and hydroquinone (HQ) are two important phenolic molecules
with recognized biological activities and industrial values. In the present study, we …

Efficient production of protocatechuic acid using systems engineering of Escherichia coli

M Wang, H Wang, C Gao, W Wei, J Liu, X Chen… - Metabolic …, 2024 - Elsevier
Abstract Protocatechuic acid (3, 4-dihydroxybenzoic acid, PCA) is widely used in the
pharmaceuticals, health food, and cosmetics industries owing to its diverse biological …

Enhanced Protocatechuic Acid Production From Glucose Using Pseudomonas putida 3-Dehydroshikimate Dehydratase Expressed in a Phenylalanine-Overproducing Mutant of …

OE Örn, S Sacchetto, EWJ van Niel… - … in bioengineering and …, 2021 - frontiersin.org
Protocatechuic acid (PCA) is a strong antioxidant and is also a potential platform for polymer
building blocks like vanillic acid, vanillin, muconic acid, and adipic acid. This report presents …

Metabolic and process engineering for microbial production of protocatechuate with Corynebacterium glutamicum

M Labib, J Görtz, C Brüsseler… - Biotechnology and …, 2021 - Wiley Online Library
Dihydroxybenzoate (protocatechuate, PCA) is a phenolic compound naturally found in
edible vegetables and medicinal herbs. PCA is of high interest in the chemical industry and …

High-Yielding Protocatechuic Acid Synthesis from l-Tyrosine in Escherichia coli

Y Chen, P Wu, LY Ko, TY Kao, L Liu… - ACS Sustainable …, 2020 - ACS Publications
Protocatechuic acid (PCA) is an important drug intermediate with antibacterial and
antioxidant properties. In this study, the whole-cell bioconversion of l-tyrosine into PCA was …

De novo biosynthesis of p-coumaric acid and caffeic acid from carboxymethyl-cellulose by microbial co-culture strategy

M Cai, J Liu, X Song, H Qi, Y Li, Z Wu, H Xu… - Microbial Cell …, 2022 - Springer
Background Aromatic compounds, such as p-coumaric acid (p-CA) and caffeic acid, are
secondary metabolites of various plants, and are widely used in diet and industry for their …