Viral nucleases from herpesviruses and coronavirus in recombination and proofreading: potential targets for antiviral drug discovery
LR Wright, DL Wright, SK Weller - Viruses, 2022 - mdpi.com
In this review, we explore recombination in two very different virus families that have become
major threats to human health. The Herpesviridae are a large family of pathogenic double …
major threats to human health. The Herpesviridae are a large family of pathogenic double …
Characterization and Inhibition of Viral Nuclease Enzymes
B Todd, G John - 2021 - era.library.ualberta.ca
Viral infection accounts for significant morbidity, mortality, and economic loss worldwide. At
no time in modern history has this been more apparent than it is now given the current …
no time in modern history has this been more apparent than it is now given the current …
[PDF][PDF] Viral Nucleases. Viruses 2023, 15, 740
Z Wang, RJ Geraghty - 2023 - pdfs.semanticscholar.org
Nucleases are ubiquitous hydrolytic enzymes that cleave phosphodiester bond of DNA
(DNases), RNA (RNases), or protein-RNA/DNA (phosphodiesterases), within the strand …
(DNases), RNA (RNases), or protein-RNA/DNA (phosphodiesterases), within the strand …
Viral Nucleases
Z Wang, RJ Geraghty - Viruses, 2023 - mdpi.com
Nucleases are ubiquitous hydrolytic enzymes that cleave phosphodiester bond of DNA
(DNases), RNA (RNases), or protein-RNA/DNA (phosphodiesterases), within the strand …
(DNases), RNA (RNases), or protein-RNA/DNA (phosphodiesterases), within the strand …
Virus‐encoded endonucleases: expected and novel functions
GS Read - Wiley Interdisciplinary Reviews: RNA, 2013 - Wiley Online Library
Endonucleases catalyze critical steps in the processing, function, and turnover of many
cellular RNAs. It is, therefore, not surprising that a number of viruses encode endonucleases …
cellular RNAs. It is, therefore, not surprising that a number of viruses encode endonucleases …
Bacteriophage SPP1 Chu is an alkaline exonuclease in the SynExo family of viral two-component recombinases
TS Vellani, RS Myers - Journal of bacteriology, 2003 - Am Soc Microbiol
Many DNA viruses concatemerize their genomes as a prerequisite to packaging into
capsids. Concatemerization arises from either replication or homologous recombination …
capsids. Concatemerization arises from either replication or homologous recombination …
Natural recombination in alphaherpesviruses: Insights into viral evolution through full genome sequencing and sequence analysis
Recombination in alphaherpesviruses was first described more than sixty years ago. Since
then, different techniques have been used to detect recombination in natural (field) and …
then, different techniques have been used to detect recombination in natural (field) and …
[HTML][HTML] New approaches to antiviral drug discovery (genomics/proteomics)
MN Prichard - Human Herpesviruses: Biology, Therapy, and …, 2007 - ncbi.nlm.nih.gov
Discovery of antiviral drugs has always been an opportunistic endeavor. Small molecules in
general and nucleoside analogues in particular have led investigators to discover …
general and nucleoside analogues in particular have led investigators to discover …
Recombination in viruses: mechanisms, methods of study, and evolutionary consequences
Recombination is a pervasive process generating diversity in most viruses. It joins variants
that arise independently within the same molecule, creating new opportunities for viruses to …
that arise independently within the same molecule, creating new opportunities for viruses to …
Structural analysis of viral ExoN domains reveals polyphyletic hijacking events
A Cruz-González, I Muñoz-Velasco, W Cottom-Salas… - PLoS …, 2021 - journals.plos.org
Nidoviruses and arenaviruses are the only known RNA viruses encoding a 3'-5'exonuclease
domain (ExoN). The proofreading activity of the ExoN domain has played a key role in the …
domain (ExoN). The proofreading activity of the ExoN domain has played a key role in the …