Next-generation sequencing of microRNAs uncovers expression signatures in polarized macrophages

V Cobos Jiménez, EJ Bradley… - Physiological …, 2014 - journals.physiology.org
microRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at a
posttranscriptional level and play a crucial role in the development of cells of the immune …

MicroRNAs in immune response and macrophage polarization

G Liu, E Abraham - Arteriosclerosis, thrombosis, and vascular …, 2013 - Am Heart Assoc
Inflammation is essential to combat invading microbial pathogens. In this process, the
involvement of multiple immune cell populations is crucial in mounting an optimum immune …

Identifying functional microRNAs in macrophages with polarized phenotypes

JW Graff, AM Dickson, G Clay, AP McCaffrey… - Journal of Biological …, 2012 - ASBMB
Macrophages respond to external stimuli with rapid changes in expression of many genes.
Different combinations of external stimuli lead to distinct polarized activation patterns …

Transcriptional regulation of macrophages polarization by MicroRNAs

H Li, T Jiang, MQ Li, XL Zheng, GJ Zhao - Frontiers in immunology, 2018 - frontiersin.org
Diversity and plasticity are the hallmarks of cells from the monocyte–macrophage lineage.
Macrophages undergo classical M1 or alternative M2 activation in response to the …

Time Series miRNA-mRNA integrated analysis reveals critical miRNAs and targets in macrophage polarization

L Lu, S McCurdy, S Huang, X Zhu, K Peplowska… - Scientific reports, 2016 - nature.com
Polarization of macrophages is regulated through complex signaling networks. Correlating
miRNA and mRNA expression over time after macrophage polarization has not yet been …

MicroRNAs are expressed and processed by human primary macrophages

AJ Luers, OD Loudig, JW Berman - Cellular immunology, 2010 - Elsevier
Macrophages are crucial to host defense, functioning in innate and cell-mediated immunity.
MicroRNAs (miRNAs) are small non-coding RNA molecules that repress transcription and …

MicroRNAs: fine tuners of monocyte heterogeneity

I Duroux-Richard, M Robin, C Peillex… - Frontiers in …, 2019 - frontiersin.org
Small non-coding microRNAs (miRNAs) have been found to play critical roles in many
biological processes by controlling gene expression at the post-transcriptional level. They …

MicroRNA: dynamic regulators of macrophage polarization and plasticity

JB Self-Fordham, AR Naqvi, JR Uttamani… - Frontiers in …, 2017 - frontiersin.org
The ability of a healthy immune system to clear the plethora of antigens it encounters
incessantly relies on the enormous plasticity displayed by the comprising cell types …

Microbial pattern recognition causes distinct functional micro-RNA signatures in primary human monocytes

R Häsler, G Jacobs, A Till, N Grabe, C Cordes… - PLoS …, 2012 - journals.plos.org
Micro-RNAs (miRNAs) are short, non-coding RNAs that regulate gene expression post
transcriptionally. Several studies have demonstrated the relevance of miRNAs for a wide …

MicroRNA regulation of macrophages in human pathologies

Y Wei, A Schober - Cellular and Molecular Life Sciences, 2016 - Springer
Macrophages play a crucial role in the innate immune system and contribute to a broad
spectrum of pathologies, like in the defence against infectious agents, in inflammation …