Microglia in neuroinflammation and neurodegeneration: from understanding to therapy

L Muzio, A Viotti, G Martino - Frontiers in neuroscience, 2021 - frontiersin.org
Microglia are the resident macrophages of the central nervous system (CNS) acting as the
first line of defense in the brain by phagocytosing harmful pathogens and cellular debris …

Microglia in neurological diseases: a road map to brain-disease dependent-inflammatory response

S Bachiller, I Jiménez-Ferrer, A Paulus… - Frontiers in cellular …, 2018 - frontiersin.org
Microglia represent a specialized population of macrophages-like cells in the central
nervous system (CNS) considered immune sentinels that are capable of orchestrating a …

Role of microglia in neurological disorders and their potentials as a therapeutic target

L Du, Y Zhang, Y Chen, J Zhu, Y Yang… - Molecular neurobiology, 2017 - Springer
Microglia are resident macrophage-like immune cells in the central nervous system (CNS)
and play a vital role in both physiological and pathological conditions, including restoring …

Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets

C Gao, J Jiang, Y Tan, S Chen - Signal transduction and targeted …, 2023 - nature.com
Microglia activation is observed in various neurodegenerative diseases. Recent advances in
single-cell technologies have revealed that these reactive microglia were with high spatial …

Microglia function in the central nervous system during health and neurodegeneration

M Colonna, O Butovsky - Annual review of immunology, 2017 - annualreviews.org
Microglia are resident cells of the brain that regulate brain development, maintenance of
neuronal networks, and injury repair. Microglia serve as brain macrophages but are distinct …

Microglia phenotype diversity

M Olah, K Biber, J Vinet… - CNS & Neurological …, 2011 - ingentaconnect.com
Microglia, the tissue macrophages of the brain, have under healthy conditions a resting
phenotype that is characterized by a ramified morphology. With their fine processes …

Microglia: the missing link to decipher and therapeutically control MS progression?

A Geladaris, D Häusler, MS Weber - International Journal of Molecular …, 2021 - mdpi.com
Therapeutically controlling chronic progression in multiple sclerosis (MS) remains a major
challenge. MS progression is defined as a steady loss of parenchymal and functional …

Microglia phenotypes in aging and neurodegenerative diseases

MY Wendimu, SB Hooks - Cells, 2022 - mdpi.com
Neuroinflammation is a hallmark of many neurodegenerative diseases (NDs) and plays a
fundamental role in mediating the onset and progression of disease. Microglia, which …

The role of microglia in the development of neurodegeneration

AR Saitgareeva, KV Bulygin, IF Gareev, OA Beylerli… - Neurological …, 2020 - Springer
Microglia-mediated central nervous system (CNS) inflammation is one of the key features of
various neurodegenerative diseases, including Parkinson's and Alzheimer's diseases. In the …

New insights into microglia–neuron interactions: a neuron's perspective

B Pósfai, C Cserép, B Orsolits, Á Dénes - Neuroscience, 2019 - Elsevier
Microglia are the primary immune cells of the central nervous system. However, recent data
indicate that microglia also contribute to diverse physiological and pathophysiological …