FSH stimulates antral follicles to grow, but its role in earlier stages, if any, is obscure. Our
aim was to determine the follicle stage at which the FSH receptor (FSHr) gene is first …

Primordial follicle formation and the subsequent transition of follicles to the primary and
secondary stages encompass the early events during folliculogenesis in mammals. These …

Insulin-like growth factor-I (IGF-I) and IGF binding protein-3 (IGFBP-3) play an important role
in regulating follicle growth and maturation. We have evaluated whether responsiveness to …

The present study was undertaken to investigate the effects of GH on follicular growth,
oocyte maturation, ovulation, and production of insulin-like growth factor-I (IGF-I) in the in …

Background. Although chronic hyperandrogenism, a typical feature of polycystic ovary
syndrome, is often associated with disturbed reproductive performance, androgens have …

Expression of the messenger ribonucleic acids (mRNAs) for insulin-like growth factors
(IGFs), their binding proteins (IGFBP1 through IGFBP-6), and receptors was examined in …

In view of recent reports on ovarian production and action of transforming growth factors
(TGFs) and inhibinrelated proteins (inhibin, activin, and follistatin), we have examined the …

The ovarian granulosa cell has recently been shown to be a site of insulin-like growth factor-
I (IGF-I) production, reception, and action. In large measure, IGF-I action (in the rat) appears …

IGF1, a potent stimulator of cellular proliferation, differentiation and development, regulates
granulosa cell steroidogenesis and apoptosis during follicular development. Depending …

The importance of endocrine signals in the regulation of follicular development has long
been recognized. However, the follicular microenvironment also plays a critical role in …