Molecular pathogenesis, targeted therapies, and future perspectives for gastric cancer

Y Zeng, RU Jin - Seminars in cancer biology, 2022 - Elsevier
Gastric cancer is a major source of global cancer mortality with limited treatment options and
poor patient survival. As our molecular understanding of gastric cancer improves, we are …

Molecular targeted therapy for the treatment of gastric cancer

W Xu, Z Yang, N Lu - Journal of Experimental & Clinical Cancer Research, 2016 - Springer
Despite the global decline in the incidence and mortality of gastric cancer, it remains one of
the most common malignant tumors of the digestive system. Although surgical resection is …

Targeted therapy for gastric cancer: molecular pathways and ongoing investigations

W Yang, A Raufi, SJ Klempner - … et Biophysica Acta (BBA)-Reviews on …, 2014 - Elsevier
Gastric cancer is currently the second leading cause of worldwide cancer mortality. Ongoing
collaborative sequencing efforts have highlighted recurrent somatic genomic aberrations in …

[HTML][HTML] Gastric cancer in the era of precision medicine

X Liu, SJ Meltzer - Cellular and molecular gastroenterology and …, 2017 - Elsevier
Gastric cancer (GC) remains the third most common cause of cancer death worldwide, with
limited therapeutic strategies available. With the advent of next-generation sequencing and …

Gastric cancer—molecular and clinical dimensions

R Wadhwa, S Song, JS Lee, Y Yao, Q Wei… - Nature reviews Clinical …, 2013 - nature.com
Gastric cancer imposes a considerable health burden around the globe despite its declining
incidence. The disease is often diagnosed in advanced stages and is associated with a poor …

[HTML][HTML] Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy

I Riquelme, K Saavedra, JA Espinoza, H Weber… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Gastric cancer (GC) is the third leading cause of cancer mortality worldwide. Although
surgical resection is a potentially curative approach for localized cases of GC, most cases of …

[HTML][HTML] New advances in targeted gastric cancer treatment

DC Lazăr, S Tăban, M Cornianu, A Faur… - World journal of …, 2016 - ncbi.nlm.nih.gov
Despite a decrease in incidence over past decades, gastric cancer remains a major global
health problem. In the more recent period, survival has shown only minor improvement …

Signaling pathways and therapeutic interventions in gastric cancer

ZN Lei, QX Teng, Q Tian, W Chen, Y Xie… - Signal transduction and …, 2022 - nature.com
Gastric cancer (GC) ranks fifth in global cancer diagnosis and fourth in cancer-related death.
Despite tremendous progress in diagnosis and therapeutic strategies and significant …

Gastric cancer: Basic aspects

S Molina‐Castro, J Pereira‐Marques… - …, 2017 - Wiley Online Library
Gastric cancer is one of the most incident and deadliest malignancies in the world. Gastric
cancer is a heterogeneous disease and the end point of a long and multistep process, which …

Gastric cancer: a primer on the epidemiology and biology of the disease and an overview of the medical management of advanced disease

MA Shah, DP Kelsen - Journal of the National Comprehensive Cancer …, 2010 - jnccn.org
Gastric cancer is a cause of significant morbidity and cancer-related mortality worldwide.
Despite recent advances in targeted therapy and understanding of the biology and …