Production technologies for monoclonal antibodies and their fragments
DC Andersen, DE Reilly - Current opinion in biotechnology, 2004 - Elsevier
In recent years, monoclonal antibodies have emerged as an increasingly important class of
human therapeutics. A variety of forms of antibodies, including fragments such as Fabs …
human therapeutics. A variety of forms of antibodies, including fragments such as Fabs …
Engineered antibody fragments and the rise of single domains
P Holliger, PJ Hudson - Nature biotechnology, 2005 - nature.com
With 18 monoclonal antibody (mAb) products currently on the market and more than 100 in
clinical trials, it is clear that engineered antibodies have come of age as biopharmaceuticals …
clinical trials, it is clear that engineered antibodies have come of age as biopharmaceuticals …
[引用][C] [33] Expression of engineered antibodies and antibody fragments in microorganisms
M Better, AH Horwitz - Methods in Enzymology, 1989 - Elsevier
Whole antibody molecules and their constituent fragments such as Fab and F (ab') 2 are in
widespread use as clinical and research reagents. In addition, these molecules either alone …
widespread use as clinical and research reagents. In addition, these molecules either alone …
Single-chain antibody fragments: Purification methodologies
LP Malpiedi, CA Diaz, BB Nerli, A Pessoa Jr - Process Biochemistry, 2013 - Elsevier
At present, single-chain variable fragments (scFv) of antibodies are considered one of the
most important tools in human therapies. Wide applications of antibodies are being …
most important tools in human therapies. Wide applications of antibodies are being …
Development trends for therapeutic antibody fragments
AL Nelson, JM Reichert - Nature biotechnology, 2009 - nature.com
Development trends for therapeutic antibody fragments | Nature Biotechnology Skip to main
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Bioengineering of antibody fragments: challenges and opportunities
S Pirkalkhoran, WR Grabowska, HH Kashkoli… - Bioengineering, 2023 - mdpi.com
Antibody fragments are used in the clinic as important therapeutic proteins for treatment of
indications where better tissue penetration and less immunogenic molecules are needed …
indications where better tissue penetration and less immunogenic molecules are needed …
Recombinant antibody fragment production
H Ma, R O'kennedy - Methods, 2017 - Elsevier
Recombinant antibodies are now very important in both therapeutics and diagnostics and
offer significant advantages over conventional antibodies. The generation of a single-chain …
offer significant advantages over conventional antibodies. The generation of a single-chain …
Therapeutic antibody production technologies: molecules, applications, expression and purification.
DP Humphreys, DJ Glover - Current opinion in drug discovery & …, 2001 - europepmc.org
Antibody-based therapeutics are currently being tested in an increasingly diverse range of
therapeutic modalities. Many different engineered formats for the antibody molecule and …
therapeutic modalities. Many different engineered formats for the antibody molecule and …
[HTML][HTML] Strategies to stabilize compact folding and minimize aggregation of antibody-based fragments
Monoclonal antibodies (mAbs) have proven to be useful for development of new therapeutic
drugs and diagnostic techniques. To overcome the difficulties posed by their complex …
drugs and diagnostic techniques. To overcome the difficulties posed by their complex …
Generation of recombinant antibodies
SM Kipriyanov, M Little - Molecular biotechnology, 1999 - Springer
Recombinant antibody technology is opening new perspectives for the development of
novel therapeutic and diagnostic agents. In this review we focus on advances in the …
novel therapeutic and diagnostic agents. In this review we focus on advances in the …