Production technologies for monoclonal antibodies and their fragments

DC Andersen, DE Reilly - Current opinion in biotechnology, 2004 - Elsevier
In recent years, monoclonal antibodies have emerged as an increasingly important class of
human therapeutics. A variety of forms of antibodies, including fragments such as Fabs …

Engineered antibody fragments and the rise of single domains

P Holliger, PJ Hudson - Nature biotechnology, 2005 - nature.com
With 18 monoclonal antibody (mAb) products currently on the market and more than 100 in
clinical trials, it is clear that engineered antibodies have come of age as biopharmaceuticals …

[引用][C] [33] Expression of engineered antibodies and antibody fragments in microorganisms

M Better, AH Horwitz - Methods in Enzymology, 1989 - Elsevier
Whole antibody molecules and their constituent fragments such as Fab and F (ab') 2 are in
widespread use as clinical and research reagents. In addition, these molecules either alone …

Single-chain antibody fragments: Purification methodologies

LP Malpiedi, CA Diaz, BB Nerli, A Pessoa Jr - Process Biochemistry, 2013 - Elsevier
At present, single-chain variable fragments (scFv) of antibodies are considered one of the
most important tools in human therapies. Wide applications of antibodies are being …

Development trends for therapeutic antibody fragments

AL Nelson, JM Reichert - Nature biotechnology, 2009 - nature.com
Development trends for therapeutic antibody fragments | Nature Biotechnology Skip to main
content Thank you for visiting nature.com. You are using a browser version with limited support …

Bioengineering of antibody fragments: challenges and opportunities

S Pirkalkhoran, WR Grabowska, HH Kashkoli… - Bioengineering, 2023 - mdpi.com
Antibody fragments are used in the clinic as important therapeutic proteins for treatment of
indications where better tissue penetration and less immunogenic molecules are needed …

Recombinant antibody fragment production

H Ma, R O'kennedy - Methods, 2017 - Elsevier
Recombinant antibodies are now very important in both therapeutics and diagnostics and
offer significant advantages over conventional antibodies. The generation of a single-chain …

Therapeutic antibody production technologies: molecules, applications, expression and purification.

DP Humphreys, DJ Glover - Current opinion in drug discovery & …, 2001 - europepmc.org
Antibody-based therapeutics are currently being tested in an increasingly diverse range of
therapeutic modalities. Many different engineered formats for the antibody molecule and …

[HTML][HTML] Strategies to stabilize compact folding and minimize aggregation of antibody-based fragments

D Gil, AG Schrum - Advances in bioscience and biotechnology …, 2013 - ncbi.nlm.nih.gov
Monoclonal antibodies (mAbs) have proven to be useful for development of new therapeutic
drugs and diagnostic techniques. To overcome the difficulties posed by their complex …

Generation of recombinant antibodies

SM Kipriyanov, M Little - Molecular biotechnology, 1999 - Springer
Recombinant antibody technology is opening new perspectives for the development of
novel therapeutic and diagnostic agents. In this review we focus on advances in the …