Relationship of type 2 diabetes to human brain pathology

JJ Pruzin, PT Nelson, EL Abner… - Neuropathology and …, 2018 - Wiley Online Library
Abstract Type 2 diabetes (T2D) and Alzheimer's disease (AD) are both highly prevalent
diseases worldwide, and each is associated with high‐morbidity and high‐mortality …

Alzheimer's disease and type 2 diabetes mellitus are distinct diseases with potential overlapping metabolic dysfunction upstream of observed cognitive decline

Y Chornenkyy, WX Wang, A Wei, PT Nelson - Brain Pathology, 2019 - Wiley Online Library
Alzheimer's disease (AD) and type 2 diabetes mellitus (T2 DM) are highly prevalent aging‐
related diseases associated with significant morbidity and mortality. Some findings in human …

Type 2 diabetes as a risk factor for Alzheimer's disease: the confounders, interactions, and neuropathology associated with this relationship

NT Vagelatos, GD Eslick - Epidemiologic reviews, 2013 - academic.oup.com
We performed a systematic review and meta-analysis to explore whether type 2 diabetes
mellitus (T2DM) increases the risk of Alzheimer's disease (AD). We also reviewed …

An update on type 2 diabetes mellitus as a risk factor for dementia

W Li, E Huang - Journal of Alzheimer's Disease, 2016 - content.iospress.com
With the rapidly expanding evidence on brain structural and functional changes in type 2
diabetes mellitus (T2DM) patients, there is an increasing need to update our understanding …

Type 2 diabetes and cognitive impairment: linking mechanisms

JA Luchsinger - Journal of Alzheimer's Disease, 2012 - content.iospress.com
This manuscript provides a brief review of current concepts in the mechanisms potentially
linking type-2-diabetes (T2D) with cognitive impairment. Existing epidemiologic studies …

The role of type 2 diabetes in neurodegeneration

G Verdile, SJ Fuller, RN Martins - Neurobiology of disease, 2015 - Elsevier
A growing body of evidence links type-2 diabetes (T2D) with dementia and
neurodegenerative diseases such as Alzheimer's disease (AD). AD is the most common …

An update on type 2 diabetes, vascular dementia and Alzheimer's disease

LG Exalto, RA Whitmer, LJ Kappele… - Experimental gerontology, 2012 - Elsevier
The risk of dementia is increased in people with type 2 diabetes mellitus (T2DM). This
review gives an update on the relation between T2DM and specific dementia subtypes–ie …

Alzheimer's disease is type 3 diabetes—evidence reviewed

SM De la Monte, JR Wands - Journal of diabetes science …, 2008 - journals.sagepub.com
Alzheimer's disease (AD) has characteristic histopathological, molecular, and biochemical
abnormalities, including cell loss; abundant neurofibrillary tangles; dystrophic neurites; …

Epidemiological approaches to understanding the link between type 2 diabetes and dementia

GT Sutherland, J Lim, V Srikanth… - Journal of Alzheimer's …, 2017 - content.iospress.com
Diabetes and dementia are two diseases that increased dramatically in most societies in
direct proportion to increases in average life expectancy. The two conditions are strongly …

Therapy Insight: type 2 diabetes mellitus and the risk of late-onset Alzheimer's disease

MN Haan - Nature clinical practice Neurology, 2006 - nature.com
A number of well-designed epidemiological studies have linked type 2 diabetes mellitus
(T2DM) with an increased risk of Alzheimer's disease (AD). Several mechanisms could help …