OBJECTIVE: Aim of present study was to evaluate changes in diffusion tensor imaging (DTI)
parameters in the whole brain of 28 patients with amyotrophic lateral sclerosis (ALS) …

BACKGROUND AND PURPOSE: ALS leads to macrostructural (ie, cortical atrophy and
hyperintensities along the corticospinal tract) and microstructural (ie, gray matter intrinsic …

In this study, we investigated whether diffusion tensor MRI (DTI) could detect progressive
corticospinal tract degeneration in amyotrophic lateral sclerosis (ALS) and whether changes …

This work evaluates the potential in diagnostic application of a new advanced neuroimaging
method, which delineates the profile of tissue properties along the corticospinal tract (CST) …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease. However, no reliable
biomarkers have been identified to represent the clinical status. This study aimed to …

Whether longitudinal diffusion tensor MRI imaging (DTI) can capture disease progression in
patients with amyotrophic lateral sclerosis (ALS) is unclear. The primary goal of this study …

Diffusion tensor imaging can identify amyotrophic lateral sclerosis-associated patterns of
brain alterations at the group level. Recently, a neuropathological staging system for …

Diffusion tensor imaging (DTI) for assessing ALS-associated white matter alterations has still
not reached the level of a neuroimaging biomarker. Since large-scale multicentre DTI …

Objective To explore the value of diffusion tensor imaging applied to those specific cerebral
white matter tracts consistently involved pathologically in amyotrophic lateral sclerosis as a …

Therapeutic development in amyotrophic lateral sclerosis (ALS) is hampered by the lack of
suitable biomarkers that might be sensitive to spatial and temporal patterns of …