During the development of the pulmonary vasculature in the fetus, many structural and
functional changes occur to prepare the lung for the transition to air breathing. The …

Acute hypoxia induces pulmonary vasoconstriction and chronic hypoxia causes structural
changes of the pulmonary vasculature including arterial medial hypertrophy. Electro-and …

1 The mechanisms responsible for sensing hypoxia and initiating hypoxic pulmonary
vasoconstriction (HPV) are unclear. We therefore examined the roles of the mitochondrial …

To determine the role of endothelium in hypoxic pulmonary vasoconstriction (HPV), we
measured vasomotor responses to hypoxia in isolated seventh-generation porcine …

Pulmonary hypertension is associated with remodelling of pulmonary vessels. Chronic
hypoxia is a common cause of pulmonary hypertension and pulmonary vascular …

Oxygen (O2) is essential for the viability and function of most metazoan organisms and thus
is closely monitored at both the organismal and the cellular levels. However, alveoli often …

Pulmonary veins have been seen primarily as conduit vessels; however, over the past two
decades, a large amount of evidence has accumulated to indicate that pulmonary veins can …

Small, muscular pulmonary arteries (PAs) constrict within seconds of the onset of alveolar
hypoxia, diverting blood flow to better-ventilated lobes, thereby matching ventilation to …

Hypoxic pulmonary vasoconstriction (HVC), an intrinsic and assumed ubiquitous response
of mammalian pulmonary blood vessels, matches regional ventilation to perfusion via an …

Background—Alveolar hypoxia acutely elicits pulmonary vasoconstriction (HPV). Chronic
hypoxia (CH), despite attenuating HPV, causes pulmonary hypertension (CH-PHT). HPV …