Sarcopenia: age-related skeletal muscle changes from determinants to physical disability

A Di Iorio, M Abate, D Di Renzo… - International journal …, 2006 - journals.sagepub.com
Human aging is characterized by skeletal muscle wasting, a debilitating condition which sets
the susceptibility for diseases that directly affect the quality of life and often limit life span …

Age-related sarcopenia and its pathophysiological bases

S Ogawa, M Yakabe, M Akishita - Inflammation and regeneration, 2016 - Springer
Age-related loss of the skeletal muscle and its function is known as sarcopenia. Definition
and diagnostic criteria for sarcopenia have been outlined as consensus statements from …

Age-related changes in skeletal muscle: changes to life-style as a therapy

R McCormick, A Vasilaki - Biogerontology, 2018 - Springer
As we age, there is an age-related loss in skeletal muscle mass and strength, known as
sarcopenia. Sarcopenia results in a decrease in mobility and independence, as well as an …

The role of inflammation in age-related sarcopenia

S Dalle, L Rossmeislova, K Koppo - Frontiers in physiology, 2017 - frontiersin.org
Many physiological changes occur with aging. These changes often, directly or indirectly,
result in a deterioration of the quality of life and even in a shortening of life expectancy …

[HTML][HTML] Sarcopenia–Molecular mechanisms and open questions

P Wiedmer, T Jung, JP Castro, LCD Pomatto… - Ageing research …, 2021 - Elsevier
Sarcopenia represents a muscle-wasting syndrome characterized by progressive and
generalized degenerative loss of skeletal muscle mass, quality, and strength occurring …

[HTML][HTML] Sarcopenia of ageing: functional, structural and biochemical alterations

S Zhong, CN Chen, LV Thompson - Brazilian journal of physical …, 2007 - SciELO Brasil
Aging is associated with a progressive decline of muscle mass, strength, and quality, a
condition described as sarcopenia of aging. Despite the significance of skeletal muscle …

Physiopathological mechanism of sarcopenia

S Walrand, C Guillet, J Salles… - Clinics in geriatric …, 2011 - geriatric.theclinics.com
Muscle erosion, which begins after the age of 55 years, is one of the most important factors
of disability in elderly people. The cumulative decline in muscle mass reaches 40% from 20 …

Sarcopenia: no consensus, no diagnostic criteria, and no approved indication—How did we get here?

WJ Evans, J Guralnik, P Cawthon, J Appleby, F Landi… - Geroscience, 2024 - Springer
In addition to the role of skeletal muscle in movement and locomotion, muscle plays a critical
role in a broad array of metabolic processes that can contribute to improved health or risk of …

Potential mechanisms underlying the role of chronic inflammation in age-related muscle wasting

E Jo, SR Lee, BS Park, JS Kim - Aging clinical and experimental research, 2012 - Springer
Sarcopenia, an age-related condition characterized by progressive skeletal muscle
degeneration, might exist as one of the primary clinical conditions underlying severe …

Mechanisms of skeletal muscle ageing; avenues for therapeutic intervention

AP Lightfoot, R McCormick, GA Nye… - Current opinion in …, 2014 - Elsevier
Highlights•Age-related loss of muscle mass and function is a major contributor to
frailty.•Muscles show loss of fibres, atrophy, poor regeneration and adaptive responses.• …