Tissue refractive index as marker of disease

Z Wang, K Tangella, A Balla… - Journal of biomedical …, 2011 - spiedigitallibrary.org
The gold standard in histopathology relies on manual investigation of stained tissue
biopsies. A sensitive and quantitative method for in situ tissue specimen inspection is highly …

Phase measurement using DIC microscopy

K Koos, B Peksel, L Kelemen - Acta Cybernetica, 2017 - cyber.bibl.u-szeged.hu
The development of fluorescent probes and proteins has helped make light microscopy
more popular by allowing the visualization of specific subcellular components, location and …

High-precision microscopic phase imaging without phase unwrapping for cancer cell identification

E Watanabe, T Hoshiba, B Javidi - Optics Letters, 2013 - opg.optica.org
Experiments for cell identification are presented using a high-precision cell phase
measurement system that does not require any phase unwrapping. This system is based on …

Three-dimensional bi-functional refractive index and fluorescence microscopy (BRIEF)

Y Xue, D Ren, L Waller - Biomedical optics express, 2022 - opg.optica.org
Fluorescence microscopy is a powerful tool for imaging biological samples with molecular
specificity. In contrast, phase microscopy provides label-free measurement of the sample's …

Tissue refractometry using Hilbert phase microscopy

N Lue, J Bewersdorf, MD Lessard, K Badizadegan… - Optics letters, 2007 - opg.optica.org
We present, for the first time to our knowledge, quantitative phase images associated with
unstained 5 μm thick tissue slices of mouse brain, spleen, and liver. The refractive properties …

Label-free classification of cell types by imaging of cell membrane fluctuations using low-coherent full-field quantitative phase microscopy

T Yamauchi, N Sugiyama, T Sakurai… - … and Processing XVII, 2010 - spiedigitallibrary.org
Cell membrane motions of living cells are quantitatively measured in nanometer resolution
by low-coherent full-field quantitative phase microscopy. Our setup is based on a full-field …

Quantitative phase imaging of live cells using fast Fourier phase microscopy

N Lue, W Choi, G Popescu, T Ikeda, RR Dasari… - Applied Optics, 2007 - opg.optica.org
Using the decomposition of an image field in two spatial components that can be
controllably shifted in phase with respect to each other, a new quantitative-phase …

Flipping interferometry and its application for quantitative phase microscopy in a micro-channel

D Roitshtain, NA Turko, B Javidi, NT Shaked - Optics letters, 2016 - opg.optica.org
We present a portable, off-axis interferometric module for quantitative phase microscopy of
live cells, positioned at the exit port of a coherently illuminated inverted microscope. The …

Towards true volumetric refractive index investigation in tomographic phase microscopy at the cellular level

M Baczewska, M Mazur, W Krauze - Optics Continuum, 2023 - opg.optica.org
Tomographic phase microscopy (TPM) is one of the most widely used quantitative phase
imaging techniques. It is a non-invasive, label-free technique that allows high-resolution …

An insight into statistical refractive index properties of cell internal structure via low-coherence statistical amplitude microscopy

P Wang, RK Bista, W Qiu, WE Khalbuss, L Zhang… - Optics express, 2010 - opg.optica.org
Refractive index properties, especially at the nanoscale, have shown great potential in
cancer diagnosis and screening. Due to the intrinsic complexity and weak refractive index …