Covering: bacterial genome sequences to 2005 and post-genomic literature to June 2006 A
total of 223 complete bacterial genomes are analyzed, with 281 citations, for the presence of …

Non-ribosomal peptide synthetases (NRPS) and type-I polyketide synthases (PKS-I) are
multimodular enzymes involved in biosynthesis of oligopeptide and polyketide secondary …

Abstract ClusterMine360 (http://www. clustermine360. ca/) is a database of microbial
polyketide and non-ribosomal peptide gene clusters. It takes advantage of crowd-sourcing …

Many bacterial and fungal secondary metabolites are produced by polyketide synthases
(PKS) and non-ribosomal peptide synthetases (NRPS). Recently, it has been discovered …

Biochemically and phylogenetically unrelated to the well‐characterized microbial polyketide
synthases (PKSs), which are responsible for the biosynthesis of many clinically important …

Polyketide synthases (PKS) perform a stepwise biosynthesis of diverse carbon skeletons
from simple activated carboxylic acid units. The products of the complex pathways possess a …

Microorganisms have invented many devious ways to thwart their foes and survive in
adverse environments. Non-motile microbes, especially ones that inhabit soil and marine …

Modular polyketide synthases (type I PKSs) in bacteria are responsible for synthesizing a
significant percentage of bioactive natural products. This group of synthases has a …

Polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) catalyze
chain elongation from simple building blocks to create a diverse array of natural products …

Polyketides are a family of complex natural products that are built from simple carboxylic
acid building blocks. In microorganisms, the majority of these secondary metabolites are …