Classification, prediction, and verification of the regioselectivity of fungal polyketide synthase product template domains
The fungal iterative nonreducing polyketide synthases (NRPKSs) synthesize aromatic
polyketides, many of which have important biological activities. The product template …
polyketides, many of which have important biological activities. The product template …
Bioinformatical analysis of the sequences, structures and functions of fungal polyketide synthase product template domains
The product template (PT) domains, specifically in fungal non-reducing polyketide synthases
(NR-PKSs), mediate the regioselective cyclization of polyketides dominating the final …
(NR-PKSs), mediate the regioselective cyclization of polyketides dominating the final …
Systematic domain swaps of iterative, nonreducing polyketide synthases provide a mechanistic understanding and rationale for catalytic reprogramming
AG Newman, AL Vagstad, PA Storm… - Journal of the …, 2014 - ACS Publications
Iterative, nonreducing polyketide synthases (NR-PKSs) are multidomain enzymes
responsible for the construction of the core architecture of aromatic polyketide natural …
responsible for the construction of the core architecture of aromatic polyketide natural …
Biosynthesis of fungal polyketides
Fungal polyketides comprise of a large group of structurally diverse compounds with a wide
range of biological activities. These compounds are biosynthesised by Type I iterative …
range of biological activities. These compounds are biosynthesised by Type I iterative …
Intrinsic and extrinsic programming of product chain length and release mode in fungal collaborating iterative polyketide synthases
Combinatorial biosynthesis with fungal polyketide synthases (PKSs) promises to produce
unprecedented bioactive “unnatural” natural products (uNPs) for drug discovery. Genome …
unprecedented bioactive “unnatural” natural products (uNPs) for drug discovery. Genome …
Unraveling the iterative type I polyketide synthases hidden in Streptomyces
Type I polyketide synthases (T1PKSs) are one of the most extensively studied PKSs, which
can act either iteratively or via an assembly-line mechanism. Domains in the T1PKSs can …
can act either iteratively or via an assembly-line mechanism. Domains in the T1PKSs can …
Navigating the fungal polyketide chemical space: from genes to molecules
The iterative type I polyketide synthases (IPKSs) are central to the biosynthesis of an
enormously diverse array of natural products in fungi. These natural products, known as …
enormously diverse array of natural products in fungi. These natural products, known as …
Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases
JF Barajas, G Shakya, G Moreno… - Proceedings of the …, 2017 - National Acad Sciences
Product template (PT) domains from fungal nonreducing polyketide synthases (NR-PKSs)
are responsible for controlling the aldol cyclizations of poly-β-ketone intermediates …
are responsible for controlling the aldol cyclizations of poly-β-ketone intermediates …
Rational domain swaps reveal insights about chain length control by ketosynthase domains in fungal nonreducing polyketide synthases
A facile genetic methodology in the filamentous fungus Aspergillus nidulans allowed
exchange of the starter unit ACP transacylase (SAT) domain in the nonreduced polyketide …
exchange of the starter unit ACP transacylase (SAT) domain in the nonreduced polyketide …
Fungal polyketide synthase product chain-length control by partnering thiohydrolase
Fungal highly reducing polyketide synthases (HRPKSs) are an enigmatic group of
multidomain enzymes that catalyze the biosynthesis of structurally diverse compounds. This …
multidomain enzymes that catalyze the biosynthesis of structurally diverse compounds. This …