This work presents the identification and proposed biosynthetic pathway for a compound of
mixed polyketide-nonribosomal peptide origin that we named acurin A. The compound was …

Production of polyketides is accomplished through complex enzymes known as polyketide
synthases (PKS); these enzymes have highly conserved domains that might be useful in …

Fungal polyketide synthase–nonribosomal peptide synthetase (PKS–NRPS) hybrids have
been characterized to produce polyketide–amino acid compounds with striking structural …

The diversity of polyketide synthase (PKS) genes in Aspergillus ochraceus NRRL 3174 and
Aspergillus carbonarius 2Mu134 has been investigated using different primer pairs …

Secondary metabolites (SMs) are low molecular weight compounds that are usually not
directly involved in growth (except siderophores) or in reproduction of their producing …

Polyketides and non-ribosomal peptides are in a class of natural products important both as
drug sources and as dangerous toxins and virulence factors. While studies over the last two …

Fungal polyketides are a diverse class of natural products, or secondary metabolites (SMs),
with a wide range of bioactivities often associated with toxicity. Here, we focus on a group of …

Analysis of fungal polyketide synthase gene sequences suggested that these might be
divided into two subclasses, designated WA-type and MSAS-type. Two pairs of degenerate …

Fungal polyketides comprise of a large group of structurally diverse compounds with a wide
range of biological activities. These compounds are biosynthesised by Type I iterative …

Fusarium species produce a plethora of bioactive polyketides and nonribosomal peptides
that give rise to health problems in animals and may have drug development potential …