Nonribosomal peptides (NRPs) and polyketides (PKs) are ecologically important secondary
metabolites produced by bacteria and fungi using multidomain enzymes called …

Myxobacterial strains producing polyketides (PKs) assumed to be biosynthesized by a type I
polyketide synthase (PKS) were analysed. Myxobacteria also produce a variety of …

Myxobacteria are prolific producers of a wide variety of secondary metabolites. The vast
majority of these compounds are complex polyketides which are biosynthesised by …

Small molecule secondary metabolites produced by organisms such as plants, bacteria, and
fungi form a fascinating and important group of natural products, many of which have shown …

Fungal highly reducing polyketide synthases (HRPKSs) are an enigmatic group of
multidomain enzymes that catalyze the biosynthesis of structurally diverse compounds. This …

Biochemical studies of purified and dissected fungal polyketide synthase and nonribosomal
peptide synthetase (PKS-NRPS) hybrid enzymes involved in biosynthesis of pseurotin and …

Fungal polyketide synthases (PKSs) can function collaboratively to synthesize natural
products of significant structural diversity. Here we present a new mode of collaboration …

Polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) catalyze
chain elongation from simple building blocks to create a diverse array of natural products …

This Viewpoint article provides a personal viewpoint of research in the area of fungal
polyketide biosynthesis. It spans the period from the first applications and subsequent …

Complex polyketides comprise a large number of natural products that have broad
application in medicine and agriculture. They are produced in bacteria and fungi from …